The Risk Assessment Information System

EPA Human Health Related Guidance

We searched the world wide web for the best available pdf copy of every document listed below and have stored it on the RAIS server. Additionally, we have created a single searchable document for each source, if multiple pdfs were provided. Although every effort has been made to obtain the best available electronic copies directly from their sources, RAIS makes no claims as to the validity, current status, or latest version of each document.

Federal Guidance

Dermal Exposure Assessment: Principles and Application. Interim Report. EPA/600/8-91/011B. Office of Research and Development, Washington, D.C. 1992.

Exposure Factors Handbook. EPA/600/8- 89/043. Office of Health and Environmental Assessment, Washington, D.C. May 1989 (March 1990).

Exposure Factors Handbook. EPA/600/8- 89/043. Office of Health and Environmental Assessment, Washington, D.C. August 1996.

Exposure Factors Handbook. EPA/600/P-95/002Fa. Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C. 1997.

Exposure Factors Handbook: 2011 Edition. EPA/600/R-090/052F. Office of Health and Environmental Assessment, Washington, D.C. September 2011.

Guidance for Conducting Remedial Investigations and Feasibility Studies Under CERCLA. Interim Final. OSWER Directive 9355.3-01. EPA/540/G-89/004. Office of Emergency and Remedial Response. U.S. Environmental Protection Agency, Washington, D.C. October 1988.

Guidance for Data Useability in Risk Assessment (Part A). EPA/540/R-92/003 U.S. Environmental Protection Agency Office of Research and Development, U.S. Environmental Protection Agency, Washington, D.C. December 1991.

Guidance for Data Useability in Risk Assessment (Part B). Publication 9285.7-09B, PB92-963362. U.S. Environmental Protection Agency Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. May 1992.

Guidelines for Exposure Assessment. U.S. Environmental Protection Agency, Risk Assessment Forum, Washington, DC, 600Z-92/001, 1992.

Health Effects Assessment Summary Tables. Annual FY-1997. EPA-540-R-97. Office of Solid Waste and Emergency Response, U.S. Environmental Protection Agency. July.

Integrated Risk Information System (IRIS). Environmental Criteria and Assessment Office. Cincinnati, OH. 1996 (or latest version).

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual. (Part A) EPA/540/1-89/002. Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. 1989.

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part B, Development of Risk-based Preliminary Remediation Goals). OSWER Directive 9285.7-01B.Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. 1991.

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part C, Risk Evaluation of Remedial Alternatives). OSWER Directive 9285.7-01C. Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. 1991.

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part D, Standardized Planning, Reporting, and Review of Superfund Risk Assessments) (Final). Publication 9285.7-47. Office of Emergency and Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. December 2001. [Excel Tables have been incorporated into the PDF file. To view the Excel files, open the PDF file in Adobe and not in a web browser. A navigation pane will be on the left that contains the embedded XLS files.]

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part E, Supplemental Guidance for Dermal Risk Assessment (Final) . OSWER Directive 9285.7-02EP.OOffice of Superfund Remediation and Technology Innovation, U.S. Environmental Protection Agency, Washington, D.C. July 2004.

Risk Assessment Guidance for Superfund: Volume I - Human Health Evaluation Manual (Part F, Supplemental Guidance for Inhalation Risk Assessment (Final) . OSWER Directive 9285.7-82. Office of Superfund Remediation and Technology Innovation, U.S. Environmental Protection Agency, Washington, D.C. January 2009. Cover memo.

Risk Assessment Guidance for Superfund Volume I: Human Health Evaluation Manual Supplemental Guidance Standard Default Exposure Factors. OSWER Directive 9285.6-03. Office of Emergency and Remedial Response. Toxics Integration Branch. 1991.

Role of Background in the CERCLA Cleanup Program, U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, Office of Emergency and Remedial Response, April 26, 2002 OSWER 9285.6-07P.

Soil Screening Guidance: User's Guide. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, July 1996. Publication 9355.4-23.

Soil Screening Guidance: Technical Background Document. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, May 1996. EPA/540/R95/128.

Soil Screening Guidance for Radionuclides: User's Guide. U.S. Environmental Protection Agency, Office of Radiation and Indoor Air, Office of Solid Waste and Emergency Response, October 2000. Publication 9355.4-16A, EPA/540-R-00-007, PB2000 963307.

Soil Screening Guidance for Radionuclides: Technical Background Document. U.S. Environmental Protection Agency, Office of Radiation and Indoor Air, Office of Solid Waste and Emergency Response, October 2000. Publication 9355.4-16, EPA/540-R-00-006, PB2000 963306.

Superfund Exposure Assessment Manual. EPA/540/1-88/001 OSWER directive 9285.5-1. U.S. Environmental Protection Agency Office of Remedial Response, U.S. Environmental Protection Agency, Washington, D.C. 1988.

Supplemental Guidance for Developing Soil Screening Levels for Superfund Sites. U.S. Environmental Protection Agency, Office of Solid Waste and Emergency Response, December 2002. Directive 9355.4-24.

Supplemental Guidance to RAGS: Calculating the Concentration Term. Publication Number 9285.7-08I. Office of Solid Waste and Emergency Response. May 1992.

Water Quality Assessment: A Screening Procedure for Toxic and Conventional Pollutants in Surface and Ground Water-Part I (Revised-1985). U.S. Environmental Protection Agency, Environmental Research Laboratory, Athens, GA 30613. EPA/600/6-85/002a. September 1985 revised.

91 document links taken from the EPA Risk Assessment Guidance webpage

Title	Date	Keywords
Guidelines for Mutagenicity Risk Assessment	1986	Guidance Document, Human Health, Chemical Mixtures
Guidelines for the Health Risk Assessment of Chemical Mixtures	1986	Guidance Document, Human Health, Children
Risk Assessment Guidance for Superfund (RAGS) Part A	1989	Superfund
Alpha2u-Globulin: Association with Chemically Induced Renal Toxicity and Neoplasia in the Male Rat	1991	Human Health, Risk Assessment, Toxicity
Guidelines for Developmental Toxicity Risk Assessment	1991	Guidance Document, Human Health, Developmental Toxicity
Risk Assessment Guidance for Superfund (RAGS) Part B	1991	Superfund
Risk Assessment Guidance for Superfund (RAGS) Part C	1991	Superfund
Provisional Guidance for Quantitative Risk Assessment of Polycyclic Aromatic Hydrocarbons	1993	Chemicals
Evaluating and Identifying Contaminants of Concern for Human Health	1994	Region 8
Model Statement of Work for RI/FS Baseline Risk Assessments of Human Health	1994	Region 8
Criteria for Evaluating Blood Lead Data Quality and Use	1995	Region 8, Lead
Estimating Site-Specific Exposure to Contaminants in Indoor Dust	1995	Region 8, Soil
Model Site Conceptual Model for RI/FS Baseline Risk Assessments of Human Health	1995	Region 8, Human Health
Policy on Evaluating Risk to Children	1995	Children
Guidelines for Reproductive Toxicity Risk Assessment	1996	Guidance Document, Reproductive Toxicity, Human Health
PCBs: Cancer Dose-Response Assessment	1996	Cancer
Sampling Manual for IEUBK Model (1996)	1996	Region 8, Lead, Modeling
Guidance on Cumulative Risk Assessment: Planning & Scoping (Part 1)	1997	Cumulative Risk
Guiding Principles for Monte Carlo Analysis	1997	Guidance Document, Human Health
Probabilistic Analysis in Risk Assessment	1997	RAF
Assessment of Thyroid Follicular Cell Tumors	1998	Assessment, Human Health
Framework for assessing non-occupational, non-dietary (residential) exposure to pesticides.	1998	Pesticides, Non-dietary
Guidelines for Neurotoxicity Risk Assessment	1998	Guidance Document, Neurotoxicity, Human Health
Research Plan for Endocrine Disruptors	1998	Human Health, Endocrine
Guidance for identifying pesticide chemicals and other substances that have a common mechanism of toxicity	1999	Pesticides, Toxicity
Summary Report for the Workshop on the Relationship Between Exposure Duration and Toxicity	1999	Exposure Duration, Toxicity
Report of the Workshop on Selecting Input Distributions for Probabilistic Assessments	1999	Human Health
Choosing a percentile of acute dietary exposure as a threshold of regulatory concern	2000	Pesticides, Regulatory
Handbook for Non-Cancer Health Effects Valuation	2000	Human Health, Cancer
Risk Characterization Handbook	2000	Risk Communication
Summary Report for the Workshop on Issues Associated with Dermal Exposure and Uptake	2000	Human Health, Dermal
The use of data on cholinesterase inhibition for risk assessments of organophosphorous and carbamate pesticides	2000	Pesticides, Inhibition
Exploration of Aging and Toxic Response	2001	Human Health, Aging
Exploration of Perinatal Pharmacokinetic Issues	2001	Human Health, Children
General principles for performing aggregate exposure and risk assessments	2001	Pesticides, Aggregate
Summary Report of the Technical Workshop on Issues Associated with Considering Developmental Changes in Behavior and Anatomy When Assessing Exposure to Children	2001	Children
Risk Assessment Guidance for Superfund (RAGS) Part D	2001	Superfund
A Review of the Reference Dose and Reference Concentration Processes	2002	Guidance Document, Human Health, RFD, RFC
Acute oral toxicity up-and-down procedure	2002	Pesticides, Oral
Consideration of the FQPA safety factor and other uncertainty factors in cumulative risk assessment of chemicals sharing a common mechanism of toxicity	2002	Pesticides, Safety, Assessment
Determination of the appropriate FQPA safety factor(s) in tolerance assessment	2002	Pesticides, Safety, Tolerance
Guidance on cumulative risk assessment of pesticide chemicals that have a common mechanism of toxicity	2002	Pesticides, Toxicity
Sample Analysis and Quality Assurance Plan for Urinary Arsenic and Blood Lead Among Residents of VBI70 Neighborhoods	2002	Region 8, Arsenic, Lead, Blood
A Summary of General Assessment Factors for Evaluating the Quality of Scientific and Technical Information	2003	Summary Report, Human Health, Exposure Factors
Framework for Cumulative Risk Assessment	2003	Human Health, Cumulative Risk
Potential Implications of Genomics for Regulatory and Risk Assessment Applications at EPA	2004	Genomics
Risk Assessment Guidance for Superfund (RAGS) Part E	2004	Superfund
Guidance for thyroid assays in pregnant animals, fetuses and post-natal animals, and adult animals	2005	Pesticides, Thyroid
Guidelines for Carcinogen Risk Assessment	2005	Guidance Document, Cancer
Supplemental Guidance for Assessing Susceptibility from Early-Life Exposure to Carcinogens	2005	Guidance Document, Cancer
A Framework for Assessing Health Risk of Environmental Exposures to Children	2006	Children, Human Health
Guidance on Selecting Age Groups for Monitoring and Assessing Childhood Exposures to Environmental Contaminants	2006	Guidance Document, Age Group Selection
Guide to Considering Children's Health When Developing EPA Actions: Implementing Executive Order 13045 and EPA's Policy on Evaluating Health Risks to Children	2006	Guidance Document, Children
Available information on assessing exposure from pesticides in food - A User's Guide	2007	Pesticides, Food
Framework for Metals Risk Assessment	2007	Metals
Nanotechnology White Paper	2007	Nanotechnology
Cumulative Health Risk Assessment of Multiple Chemicals, Exposures, and Effects: A Resource Document	2008	Cumulative Risk
Considerations for Developing a Dosimetry-Based Cumulative Risk Assessment Approach for Mixtures of Environmental Contaminants	2009	Technical Guidance, Cumulative Risk
EPA's Strategic Plan for Evaluating the Toxicity of Chemicals	2009	Chemicals
Scientific and Ethical Approaches for Observational Exposure Studies	2009	Approaches, Exposure Studies
Risk Assessment Guidance for Superfund (RAGS) Part F	2009	Superfund
Dioxin Toxicity Equivalency Factors (TEFs) for Human Health	2010	Human Health, Dioxin, TEF
Exposure Factors Handbook	2011	Human Health, Exposure Factors, children
Recommended Use of Body Weight 3/4 as the Default Method in Derivation of the Oral Reference Dose	2011	Human Health, RFD
Use of the local lymph node assay and reduced dose protocol for LLNA in assessing pesticide products	2011	Pesticides, Assessment
Benchmark Dose Technical Guidance	2012	Technical Guidance, BMDS, Modeling, Assessments
EPA Scientific Integrity Policy	2012	Policies
Guidance for waiving or bridging of mammalian acute toxicity tests for pesticides and pesticide products	2012	Pesticides, Toxicity Tests
Guideline for Microbial Risk Assessment: Pathogenic Microorganisms with Focus on Food and Water	2012	Guidance Document, Human Health, Pathogens
Standard Operating Procedure: In Vitro Bioacessibility (IVBA) Procedure for Arsenic	2012	Region 8
Standard operating procedures for residential pesticide exposure assessment	2012	Pesticides, Residential
Conflicts of Interest Review Process for Contractor-Managed Peer Reviews of EPA Highly Influential Scientific Assessment (HISA) and Influential Scientific Information (ISI) Documents	2013	Peer Review
Part 58 toxicology data requirements: guidance for neurotoxicity battery, subchronic inhalation, subchronic dermal and immunotoxicity studies	2013	Pesticides, Neurotoxicity
Developing a tiered framework for extrapolation modeling	2014	Pesticides, Extrapolation
EPA Positive Matrix Factorization (PMF) 5.0 Fundamentals and User Guide	2014	PMF
Framework for Human Health Risk Assessment to Inform Decision Making	2014	Framework, Human Health
Guidance for Applying Quantitative Data to Develop Data-Derived Extrapolation Factors for Interspecies and Intraspecies Extrapolation	2014	Guidance Document, Toxicokinetic, Toxicodynamic
Risk Assessment Forum White Paper: Probabilistic Risk Assessment Methods and Case Studies	2014	Case Studies, Human Health
Process for establishing and implementing alternative approaches to traditional in vivo acute toxicity studies	2014	Pesticides, Vivo Acute Toxicity
Revised Methods for Worker Risk Assessment	2014	Pesticides, Worker, Methods
Alternate testing framework for classification of eye irritation potential of EPA-regulated pesticide products	2015	Pesticides, Classification
Indirect Dietary Residential Exposure Assessment Model (IDREAM) Implementation	2015	Pesticides, Exposure
Occupational pesticide handler exposure data	2015	Pesticides, Handler
Peer Review Handbook - 4th Edition	2015	Peer Review
Guidelines for Human Exposure Assessment	2019	Guidance Document, Human Health, Exposure
Advances in genetic toxicology and integration of in vivo testing into standard repeat dose studies	various	Pesticides, Toxicology
Occupational pesticide post-application exposure data	various	Pesticides, Post-Application

The Risk Assessment Information System

EPA Human Health Risk Assessment Guidance

EPA Human Health Related Guidance

Federal Guidance

91 document links taken from the EPA Risk Assessment Guidance webpage

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