All risk assessment activities should follow the guidelines provided by the EPA in Risk Assessment Guidance for Superfund: Volume I, Human Health Evaluation Manual (Part A, B, C, D, E & F), EPA/540/1-89/002 and Guidance for Conducting Remedial Investigations and Feasibility Studies under CERCLA, EPA/540/G-89/004.

Region 1 Risk Assessment (serving CT, ME, MA, NH, RI, and VT)

Region 2 Risk Assessment (serving NJ, NY, Puerto Rico, the U.S. Virgin Islands and 8 federally recognized Indian Nations)

Region 3 Risk Assessment (serving DE, DC, MD, PA, VA, WV and 7 federally recognized tribes)

Region 4 Risk Assessment (serving AL, FL, GA, KY, MS, NC, SC, and TN)

Region 4 Human Health Risk Assessment Supplemental Guidance (March 2018 Update). Scientific Support Section Superfund Division. 2018.

Region 4 Ecological Risk Assessment Supplemental Guidance (March 2018 Update). Scientific Support Section Superfund Division. 2018.

Region 5 Risk Assessment (serving IL, IN, MI, MN, OH, and WI)

Region 6 Risk Assessment (serving AR, LA, NM, OK, and TX)

Region 7 Risk Assessment (serving IA, KS, MO, and NE)

Region 8 Risk Assessment (serving CO, MT, ND, SD, UT, and WY)

Region 9 Risk Assessment (serving AZ, CA, HI, NV, American Samoa, Commonwealth of the Northern Mariana Islands, Federated States of Micronesia, Guam, Marshall Islands, and Republic of Palau)

Region 10 Risk Assessment (serving AK, ID, OR, WA and 271 native tribes)