ACENAPHTHENE 000083-32-9
NOAEL 175 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS LIVER HEPATOTOXICITY 6E-1 IRIS 010165
300
ACENAPTHYLENE 000208-96-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005202
ACEPHATE 030560-19-1
LOAEL 2 PPM RAT
ORAL: DIET 13 WEEKS BRAIN DECREASED CHOLINESTERASE 4E-3 IRIS 005833
ACTIVITY 30
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ACETONE 000067-64-1
NOEL 100 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER INCREASED WEIGHT 1E+0 IRIS 005204
KIDNEY INCREASED WEIGHT 100
KIDNEY NEPHROTOXICITY
ACETONE CYANOHYDRIN / (2-METHYLLACTONITRILE) 000075-86-5
NOAEL 8.75 MG/(KG-DAY) RAT
ORAL: GAVAGE 90 DAYS LIVER INCREASED RELATIVE WEIGHT 8E-3 8E-4 005776
300 3000
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ACETONITRILE 000075-05-8
NOAEL 100 PPM MOUSE
INHALATION: 92 DAYS ERYTHROCYTES DECREASED CELL COUNT 6E-2 IRIS 005210
INTERMITTENT BLOOD DECREASED HEMATOCRIT 300
LIVER HEPATIC LESIONS
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5. UNDER REVIEW, CURRENT NUMBER SUBJECT TO
CHANGE.
ACETOPHENONE 000098-86-2
NOAEL 10,000 PPM RAT
ORAL: DIET 17 WEEKS NONE OBSERVED 1E+0 IRIS 005212
300
010874
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
ACROLEIN 000107-02-8
NOAEL 15.6 MG/KG/DAY RAT
ORAL: WATER 90 DAYS 2E-2 010390
1000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010856
ACRYLAMIDE 000079-06-1
NOEL 0.2 MG/KG/DAY RAT
ORAL: DRINKING 90 DAYS NERVE DAMAGE 2E-3 IRIS 005835
WATER 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010876
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfD/RfC WORK GROUP.
ACRYLIC ACID 000079-10-7
NOAEL 53 MG/KG/DAY RAT
ORAL: DRINKING 2 GENERATION WHOLE BODY DECREASED PUP WEIGHT 5E-1 IRIS 005836
WATER 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD ON IRIS WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
LOAEL 5 PPM MOUSE
INHALATION: 13 WEEKS NASAL MUCOSA LESIONS 3E-3 IRIS 010346
INTERMITTENT 100
ACRYLONITRILE 000107-13-1
NOAEL 1 MG/(KG-DAY) MOUSE
ORAL: GAVAGE 60 DAYS TESTES DECREASED SPERM COUNTS 1E-2 1E-3 010939
TESTES SEMINIFEROUS TUBULE 100 1000
DEGENERATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] UNDER REVIEW BY THE RfD/RfC WORK GROUP WAS MODIFIED TO ESTIMATE THE
SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
ADIPONITRILE 000111-69-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005157
ALACHLOR 015972-60-8
NOEL 1 MG/KG/DAY DOG
ORAL: CAPSULE 1 YEAR BLOOD ANEMIA 1E-2 IRIS 005837
SITES, MULTIPLE HEMOSIDEROSIS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALDICARB 000116-06-3
NOAEL 0.01 MG/KG-DAY HUMAN
ORAL ACUTE CENTRAL NERVOUS SWEATING 1E-3 IRIS 010960
SYSTEM 10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: CLINICAL SIGNS OF ACETYL CHOLINESTERASE INHIBITION INCLUDING SWEATING, PINPOINT PUPILS, LEG WEAKNESS, NAUSEA, DIARRHEA
AND OTHER EFFECTS WERE OBSERVED IN THE PRINCIPAL AND SUPPORTING STUDIES.
ALDRIN 000309-00-2
LOAEL 0.025 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER LESIONS 3E-5 IRIS 005159
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALLIDOCHLOR 000093-71-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005838
ALLYL ALCOHOL 000107-18-6
NOEL 50 PPM RAT
ORAL: DRINKING 15 WEEKS LIVER EFFECTS 5E-2 IRIS 005839
WATER KIDNEY EFFECTS 100
ALLYL CHLORIDE 000107-05-1
NOAEL 17 MG/CU M RABBIT
INHALATION: 5 MONTHS NERVOUS SYSTEM NEUROTOXICITY 1E-2 IRIS 010369
INTERMITTENT 300
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ALUMINUM 007429-90-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005162
ALUMINUM PHOSPHIDE 020859-73-8
NOAEL 0.43 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY ALTERED WEIGHT 4E-4 IRIS 010255
UNSPECIFIED ALTERED CLINICAL PARAMETERS 100
AMETRYN 000834-12-8
NOEL 10 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER EFFECTS 9E-2 IRIS 005841
100
AMINO-2-NAPHTHOL, 1- 002834-92-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005842
AMINO-2-NAPHTOL HYDROCHLORIDE, 1- 001198-27-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005843
AMINOPHENOL, M- 000591-27-5
NOAEL 1300 PPM RAT
ORAL: DIET 13 WEEKS WHOLE BODY ALTERED WEIGHT 7E-1 7E-2 005844
THYROID ALTERED WEIGHT 100 1000
AMINOPHENOL, O- 000095-55-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005845
AMINOPHENOL, P- 000123-30-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005846
AMINOPYRIDINE, 4- 000504-24-5
NOAEL 3 PPM RAT
ORAL: DIET 90 DAYS LIVER INCREASED WEIGHT 2E-4 2E-5 005847
BRAIN INCREASED WEIGHT 1000 10000
AMMONIA 007664-41-7
NOAEL 34 MG/L HUMAN
ORAL: DRINKING SENSORY TASTE THRESHOLD 34 MG/L 34 MG/L 005166
WATER 1 1
SUBCHRONIC [RfD] COMMENT: GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
SAFE CONCENTRATION MAY BE HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
CHRONIC [RfD] COMMENT: GIVEN AS CONCENTRATION IN DRINKING WATER. SPECIFICALLY RELATED TO ORGANOLEPTIC THRESHOLD.
SAFE CONCENTRATION MAY BE HIGHER, BUT DATA ARE INADEQUATE TO ASSESS.
NOAEL 6.4 MG/CU M HUMAN
INHALATION: NASAL CAVITY RHINITIS 1E-1 IRIS 010392
INTERMITTENT LUNGS PNEUMONIA 30
LUNGS LESIONS
ANILINE 000062-53-3
NOAEL 19 MG/CU M MOUSE
INHALATION: 20-26 WEEKS SPLEEN PATHOLOGY 1E-2 IRIS 010370
INTERMITTENT 300
RAT
20-26 WEEKS SPLEEN PATHOLOGY
GUINEA PIG
20-26 WEEKS SPLEEN PATHOLOGY
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ANTHRACENE 000120-12-7
NOEL 1000 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS NONE OBSERVED 3E+0 IRIS 010166
300
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP. 010964
ANTIMONY PENTOXIDE 001314-60-9
LOAEL 0.46 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME WHOLE BODY INCREASED MORTALITY 5E-4 5E-4 005174
WATER BLOOD ALTERED CHEMISTRIES 1000 1000
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY POTASSIUM TARTRATE 000304-61-0
LOAEL 0.91 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME WHOLE BODY INCREASED MORTALITY 9E-4 9E-4 005234
WATER BLOOD ALTERED CHEMISTRIES 1000 1000
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TETROXIDE 001332-81-6
LOAEL 0.44 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME WHOLE BODY INCREASED MORTALITY 4E-4 4E-4 005238
WATER BLOOD ALTERED CHEMISTRIES 1000 1000
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ANTIMONY TRIOXIDE 001309-64-4
LOAEL 0.42 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME WHOLE BODY INCREASED MORTALITY 4E-4 4E-4 005242
WATER BLOOD ALTERED CHEMISTRIES 1000 1000
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ANTIMONY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
BMC 0.87 MG/CU M RAT
INHALATION, 1 YEAR LUNG PULMONARY TOXICITY 2E-4 IRIS 010974
INTERMITTENT LUNG INTERSTITIAL INFLAMMATION, 30
CHRONIC
CHRONIC RfC COMMENT: A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfC.
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC IS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
ANTIMONY, METALLIC 007440-36-0
LOAEL 0.35 MG SB/KG/DAY RAT
ORAL: DRINKING LIFETIME WHOLE BODY INCREASED MORTALITY 4E-4 IRIS 005170
WATER BLOOD ALTERED CHEMISTRIES 1000
ARAMITE 000140-57-8
NOAEL 100 PPM RAT
ORAL: DIET 104 WEEKS LIVER INCREASED WEIGHT 5E-2 005850
100
NOAEL 500 PPM DOG
ORAL: DIET 52 WEEKS LIVER DEGENERATION 1E-1 005849
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
AROCLOR 1248 012672-29-6
IRIS
CHRONIC RfD COMMENT: THE CHRONIC ORAL RfD IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP. 010940
AROCLOR 1254 011097-69-1
LOAEL 0.005 MG/KG/DAY
ORAL: CAPSULE MONKEY IMMUNE SYSTEM TOXICITY 5E-5 IRIS 010963
>5 YEARS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
ARSENIC, INORGANIC 007440-38-2
NOAEL 0.009 MG/L HUMAN
ORAL SKIN KERATOSIS 3E-4 IRIS 010434
SKIN HYPERPIGMENTATION 3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
ATRAZINE 001912-24-9
NOEL 3.5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 3.5E-2 IRIS 010855
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BARIUM 007440-39-3
NOAEL 0.21 MG/KG/DAY HUMAN
ORAL: WATER 10 WEEKS CARDIOVASCULAR INCREASED BLOOD PRESSURE 7E-2 IRIS 010348
SYSTEM 3
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
BARIUM CYANIDE 000542-62-1
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP. 010941
BENEFIN 001861-40-1
NOAEL 25 MG/KG/DAY DOG
ORAL: DIET 1 YEAR ERYTHROCYTE DECREASED COUNT 3E-1 IRIS 005852
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BENZAL CHLORIDE 000098-87-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005853
BENZALDEHYDE 000100-52-7
NOEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS KIDNEY EFFECTS 1E+0 IRIS 005854
FORESTOMACH LESIONS 100
SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
BENZALDEHYDE CYANOHYDRIN 000532-28-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005781
BENZENE 000071-43-2
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BENZENETHIOL / (THIOPHENOL) 000108-98-5
LOAEL 0.1 MG/(KG-DAY) RAT
ORAL: GAVAGE 90 DAYS LIVER CENTRILOBULAR EOSINOPHILIC 1E-4 1E-5 010942
CHANGES 1000 10,000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] UNDER REVIEW BY THE RfD/RfC WORKGROUP WAS MODIFIED TO ESTIMATE THE
SUBCHRONIC ORAL [RfD].
BENZIDINE 000092-87-5
LOAEL 2.7 MG/KG/DAY MOUSE
ORAL: DRINKING 33 MONTHS BRAIN CELLULAR CHANGES 3E-3 IRIS 005830
WATER LIVER CELLULAR CHANGES 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010877
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (03/28/91) BY THE RfD/RfC WORK GROUP.
BENZO[A]ANTHRACENE 000056-55-3
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP. 010965
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BENZOIC ACID 000065-85-0
NOAEL 312 MG/DAY HUMAN
ORAL: DIET NONE OBSERVED 4E+0 IRIS 005260
1
SUBCHRONIC [RfD] COMMENT: THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL. THE CHRONIC ORAL RfD
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE HUMAN DAILY PER CAPITA INTAKE WAS USED AS THE CRITICAL DOSE LEVEL.
BENZYL ALCOHOL 000100-51-6
LOAEL 286 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS FORESTOMACH EPITHELIAL HYPERPLASIA 3E-1 005855
1000
NOAEL 143 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT 1E+0 005856
100
BERYLLIUM 007440-41-7
NOAEL 0.54 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME NONE OBSERVED 5E-3 IRIS 005262
BIPHENYL, 1,1' 000092-52-4
NOAEL 50 MG/KG/DAY RAT
ORAL: DIET 700 DAYS KIDNEY DAMAGE 5E-2 IRIS 005857
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 010878
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (09/20/90) BY THE RfD/RfC WORK GROUP.
BIS(2-CHLOROISOPROPYL) ETHER 039638-32-9
NOAEL 35.8 MG/KG/DAY MOUSE
ORAL: DIET 2 YEARS ERYTHROCYTES DECREASED HEMOGLOBIN 4E-2 IRIS 010257
1000
BIS(2-ETHYLHEXYL) PHTHALATE / (DEHP) 000117-81-7
IRIS 010859
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BISPHENOL A 000080-05-7
IRIS 005268
NOAEL 750 PPM RAT
ORAL 13 WEEKS WHOLE BODY DECREASED WEIGHT 6E-1 005266
100
BORON TRIFLUORIDE 007637-07-2
NOAEL 6 MG/CU M RAT
INHALATION: 13 WEEKS KIDNEY NECROSIS 7E-3 7E-4 010395
INTERMITTENT 300 3000
BORON, ELEMENTAL 007440-42-8
NOAEL 8.8 MG/KG/DAY DOG
ORAL: DIET 2 YEARS TESTIS LESIONS IRIS 005272
SUBCHRONIC [RfD] COMMENT: THE SUBCHRONIC ORAL [RfD] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD UPON WHICH IT WAS BASED IS
UNDER REVIEW BY THE RfD/RfC WORK GROUP.
CHRONIC RfD COMMENT: THE CHRONIC ORAL RfD, WHILE STILL ON IRIS, IS BEING RECONSIDERED BY THE RfD/RfC WORK GROUP.
LOAEL 4.5 MG/CU M HUMAN
INHALATION: RESPIRATORY IRRITATION 2E-2 2E-2 005269
INTERMITTENT TRACT 100 100
BRONCHUS BRONCHITIS
SUBCHRONIC [RfC] COMMENT: THE SUBCHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS SPECIFICALLY FOR ANHYDROUS BORAX.
BROMINATED DIBENZO-P-DIOXINS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005858
BROMINATED DIBENZOFURANS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005859
BROMOACETONE 000598-31-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005860
BROMOCHLOROETHANES
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005861
BROMODICHLOROMETHANE 000075-27-4
LOAEL 17.9 MG/KG/DAY MOUSE
ORAL: GAVAGE 102 WEEKS KIDNEY CYTOMEGALY 2E-2 IRIS 005715
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOETHENE / (VINYL BROMIDE) 000593-60-2
LOAEL 9.7 PPM RAT
INHALATION: 24 MONTHS LIVER HYPERTROPHY 3E-3 IRIS 010929
INTERMITTENT LIVER BASOPHILIC FOCI 3000
LIVER EOSINOPHILIC FOCI
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BROMOFORM 000075-25-2
NOEL 17.9 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER EFFECTS 2E-1 IRIS 005722
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010961
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
BROMOMETHANE 000074-83-9
IRIS 010861
IRIS 010860
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
BROMOPHENYL PHENYL ETHER, 4- 000101-55-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005864
BROMOPHOS 002104-96-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 3 BLOOD DECREASED CHOLINESTERASE 5E-2 5E-3 005865
GENERATIONS ACTIVITY 100 1000
LIVER DECREASED CHOLINESTERASE
ACTIVITY
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
BROMOXYNIL 001689-84-5
NOEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS NONE OBSERVED 2E-2 IRIS 005866
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BROMOXYNIL OCTANOATE 001689-99-2
NOEL 7.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS NONE OBSERVED 2E-2 IRIS 005867
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BUSAN 77 031512-74-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005868
BUSAN 90 002491-38-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005869
BUTANOL, 1- 000071-36-3
NOAEL 125 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS CENTRAL NERVOUS HYPOACTIVITY 1E+0 IRIS 005870
SYSTEM 100
CENTRAL NERVOUS ATAXIA
SYSTEM
BUTYL BENZYL PHTHALATE, N- 000085-68-7
NOAEL 159 MG/KG/DAY RAT
ORAL: DIET 26 WEEKS LIVER ALTERED WEIGHT 2E+0 IRIS 005616
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
BUTYLATE 002008-41-5
NOEL 5 MG/KG/DAY DOG
ORAL: CAPSULE 12 MONTHS LIVER INCREASED RELATIVE WEIGHT 5E-2 IRIS 005871
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
BUTYLCHLORIDE, T- 000507-20-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005810
BUTYROLACTONE, GAMMA- 000096-48-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005872
CACODYLIC ACID 000075-60-5
NOEL 9.2 MG/KG/DAY RAT
ORAL: DIET 90 DAYS NONE OBSERVED 3E-2 3E-3 005873
300 3000
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO ARSENIC BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CADMIUM 007440-43-9
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY. IRIS 005280
CALCIUM CYANIDE 000592-01-8
NOAEL 19.1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 4E-2 IRIS 010258
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CAPROLACTAM 000105-60-2
IRIS 005284
NOAEL 50 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY EFFECTS 5E-1 005282
100
IRIS 010966
CAPTAFOL 002425-06-1
LOAEL 2 MG/KG/DAY DOG
ORAL: CAPSULE 12 MONTHS KIDNEY EFFECTS 2E-3 IRIS 005874
BLADDER EFFECTS 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CAPTAN 000133-06-2
NOEL 12.5 MG/KG/DAY RAT
ORAL: DIET WHOLE BODY DECREASED WEIGHT 1.3E-1 IRIS 005875
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
CHRONIC [RfD] COMMENT: BASED ON A MULTI-GENERATION REPRODUCTION STUDY.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CARBARYL 000063-25-2
NOAEL 9.6 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY TOXICITY 1E-1 IRIS 005876
LIVER TOXICITY 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 010882
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (08/15/91) BY THE RfD/RfC WORK GROUP.
CARBOFURAN 001563-66-2
NOEL 0.5 MG/KG/DAY DOG
ORAL: DIET 1 YEAR BLOOD CHOLINESTERASE INHIBITION 5E-3 IRIS 005877
TESTIS EFFECTS 100
UTERUS EFFECTS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CARBON DISULFIDE 000075-15-0
NOEL 11 MG/KG/DAY RABBIT
INHALATION: FETUS TOXICITY 1E-1 IRIS 010259
INTERMITTENT 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS DETERMINED FROM A TERATOLOGY STUDY WITH EXPOSURES BEFORE AND DURING
THE ENTIRE GESTATION PERIOD.
BMC 19.7 MG/CU M HUMAN OCCUPATIONAL
INHALATION: 12.1 +/- PERIPHERAL DYSFUNCTION 7E-1 IRIS 010975
INTERMITTENT 6.9 YEARS NERVOUS SYSTEM 30
CHRONIC RfC COMMENT: A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfC.
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CARBON MONOXIDE 000630-05-0
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010493
CARBON TETRACHLORIDE 000056-23-5
IRIS 010862
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORAL 000075-87-6
LOAEL 15.7 MG/KG/DAY MOUSE
ORAL: DRINKING 90 DAYS LIVER EFFECTS 2E-2 IRIS 005290
WATER 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLORDANE 000057-74-9
NOEL 0.055 MG/KG/DAY RAT
ORAL: DIET 130 WEEKS LIVER HYPERTROPHY 6E-5 IRIS 005296
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORINE CYANIDE 000506-77-4
NOAEL 25.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 5E-2 IRIS 010261
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLORO-1,3-BUTADIENE, 2- / (CHLOROPRENE) 000126-99-8
NOAEL 32 PPM RAT
INHALATION 90 DAYS OLFACTORY DEGENERATION 7E-2 7E-3 010515
EPITHELIUM 30 300
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHLORO-M-CRESOL, P- 000059-50-7
NOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 28 DAYS WHOLE BODY DECREASED WEIGHT GAIN 2E+0 005366
100
CHLOROACETALDEHYDE 000107-20-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005342
CHLOROACETIC ACID 000079-11-8
LOAEL 30 MG/KG RAT
ORAL: GAVAGE 13 WEEKS HEART MYOCARDITIS 2E-2 2E-3 005346
1000 10000
CHLOROANILINE, 2- 000095-51-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005347
CHLOROANILINE, 3- 000108-42-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005348
CHLOROANILINE, 4- 000106-47-8
LOAEL 12.5 MG/KG/DAY RAT
ORAL: DIET 78 WEEKS SPLEEN PROLIFERATIVE LESIONS 4E-3 IRIS 005349
3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLOROBENZENE 000108-90-7
IRIS 010863
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHLOROBENZILATE 000510-15-6
NOEL 5 MG/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS GASTRO- DECREASED STOOL QUANTITY 2E-2 IRIS 010260
INTESTINAL SYSTEM 300
WHOLE BODY DECREASED FOOD CONSUMPTION
WHOLE BODY DECREASED WEIGHT GAIN
NERVOUS SYSTEM HYPERIRRITABILITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. BASED ON A TERATOLOGY STUDY WITH
EXPOSURES DURING DAYS 7-19 OF GESTATION.
CHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURES DURING DAYS 7-19 OF GESTATION.
010931
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP.
CHLOROBENZOIC ACID, P- 000074-11-3
NOAEL 26 MG/DAY RAT
ORAL: DIET 5 MONTHS NONE OBSERVED 2E+0 2E-1 005360
100 1000
CHLOROBENZOTRIFLUORIDE, 4- 000098-56-6
NOAEL 15 MG/KG/DAY RAT
ORAL: GAVAGE KIDNEY TUBULAR DEGENERATION 2E-1 2E-2 005364
100 1000
SUBCHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING,
DURING GESTATION, AND FOR 90 DAYS POST-WEANING.
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES 4 WEEKS PRIOR TO MATING, DURING
GESTATION, AND FOR 90 DAYS POST-WEANING.
CHLOROBUTANE, 1- 000109-69-3
NOAEL 43 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS WHOLE BODY INCREASED MORTALITY 4E-1 005808
CENTRAL NERVOUS EFFECTS 100
SYSTEM
BLOOD HEMATOLOGIC EFFECTS
NOAEL 86 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY DECREASED WEIGHT GAIN 9E-1 005806
CENTRAL NERVOUS EFFECTS 100
SYSTEM
SPLEEN HEMATOPOIESIS
CHLOROBUTANE, 2- 000078-86-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005809
CHLOROCYCLOPENTADIENE 041851-50-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005297
CHLOROFORM 000067-66-3
LOAEL 12.9 MG/KG/DAY DOG
ORAL: CAPSULE 7.5 YEARS LIVER LESIONS 1E-2 IRIS 005372
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHLOROMETHANE / (METHYL CHLORIDE) 000074-87-3
010005
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORONITROBENZENE, M- 000121-73-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005879
CHLOROPHENOL, 2- 000095-57-8
NOAEL 50 PPM RAT
ORAL: DRINKING REPRODUCTION REPRODUCTIVE EFFECTS 5E-2 IRIS 010436
WATER 100
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTIVE STUDY WITH EXPOSURE 10 WEEKS PRIOR TO AND DURING MATING, GESTATION AND WEANING.
CHLOROPHENOL, 3- 000108-43-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005309
CHLOROPHENOL, 4- 000106-48-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005310
CHLOROPROPANE, 2- 000075-29-6
NOAEL 91.4 MG/KG/DAY RAT
INHALATION: 4 WEEKS LIVER EFFECTS 1E+0 1E-1 010444
INTERMITTENT 100 1000
CHLOROTOLUENE, M- 000108-41-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005880
CHLOROTOLUENE, O- 000095-49-8
NOAEL 20 MG/KG/DAY RAT
ORAL: GAVAGE 103 DAYS WHOLE BODY DECREASED WEIGHT GAIN 2E-1 IRIS 010167
100
CHLOROTOLUENE, P- 000106-43-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 010200
CHLORPYRIFOS 002921-88-2
NOEL 0.03 MG/KG/DAY HUMAN
ORAL: CAPSULE 20 DAYS OR BLOOD DECREASED CHOLINESTERASE 3E-3 IRIS 005881
9 DAYS ACTIVITY 10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHLORPYRIFOS METHYL 005598-13-0
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 3 REPRODUCTION DECREASED FERTILITY 1E-2 1E-2 005882
GENERATIONS 100 100
RAT
2 YEARS LIVER EFFECTS
CHLOROTHALONIL 001897-45-6
NOEL 1.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS KIDNEY EFFECTS 1.5E-2 IRIS 005883
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CHLORTHIOPHOS 060238-56-4
NOAEL 0.08 MG/KG/DAY RAT
ORAL: DIET 2 YEARS NONE OBSERVED 8E-4 8E-4 005884
100 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHROMIUM(III) 016065-83-1
NOEL 5 % (CR2O3) RAT
ORAL: DIET 840 DAYS NONE OBSERVED 1E+0 IRIS 005731
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHROMIUM(VI) 018540-29-9
NOAEL 2.4 MG/KG/DAY RAT
ORAL: DRINKING 1 YEAR NONE OBSERVED 2E-2 IRIS 005522
WATER 100
CHRONIC [RfC] COMMENT: INHALATION ISSUES ARE UNDER REVIEW BY THE RFD/RFC WORK GROUP.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
CHRYSENE 000218-01-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY. 005885
COPPER 007440-50-8
LOAEL 5.3 MG HUMAN
ORAL SINGLE DOSE GASTRO- IRRITATION 1.3 MG/L 1.3 MG/L 005374
INTESTINAL SYSTEM
SUBCHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. DWCD (1987) CONCLUDED TOXICITY DATA WERE
INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
CHRONIC [RfD] COMMENT: CURRENT DRINKING WATER STANDARD OF 1.3 MG/L. DWCD (1987) CONCLUDED TOXICITY DATA WERE
INADEQUATE FOR CALCULATION OF AN RfD FOR COPPER.
COPPER CYANIDE 000544-92-3
NOAEL 5 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER HISTOPATHOLOGY 5E-2 IRIS 010262
KIDNEY HISTOPATHOLOGY 100
WHOLE BODY DECREASED WEIGHT
ORGANS DECREASED WEIGHT
CRESOL, M- / (3-METHYLPHENOL) 000108-39-4
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN 5E-1 IRIS 005380
NERVOUS SYSTEM NEUROTOXICITY 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010888
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
CRESOL, O- / (2-METHYLPHENOL) 000095-48-7
NOAEL 50 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN 5E-1 IRIS 005384
NERVOUS SYSTEM NEUROTOXICITY 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010889
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
CRESOL, P- / (4-METHYLPHENOL) 000106-44-5
NOAEL 5 MG/(KG-DAY) RABBIT
ORAL: GAVAGE GESTATION CENTRAL NERVOUS HYPOACTIVITY 5E-3 5E-3 010516
DAYS 6-18 SYSTEM 1000 1000
RESPIRATORY DISTRESS
SYSTEM
WHOLE BODY MATERNAL DEATH
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010890
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
CUMENE 000098-82-8
NOAEL 154 MG/KG/DAY RAT
ORAL: GAVAGE 194 DAYS KIDNEY INCREASED WEIGHT 4E-1 IRIS 005392
300
NOAEL 105.1 PPM RAT
INHALATION: 4 WEEKS CENTRAL NERVOUS INVOLVEMENT 9E-2 9E-3 005908
INTERMITTENT SYSTEM 1000 10000
NOSE IRRITATION
CYANAZINE 021725-46-2
NOEL 0.625 MG/KG/DAY DOG
ORAL: DIET 1 YEAR WHOLE BODY DECREASED WEIGHT 2E-3 2E-3 010411
BLOOD INCREASED PLATELET COUNT 300 300
BLOOD ALTERED CLINICAL CHEMISTRY
PARAMETERS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS (07/01/92). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
CYANIDE 000057-12-5
NOAEL 10.8 MG/KG/DAY RAT
ORAL: DIET 104 WEEKS WHOLE BODY DECREASED WEIGHT 2E-2 IRIS 005396
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: THE CASRN FOR CN- IS 000057-12-5; THE CASRN FOR HCN IS 000074-90-8.
CYANOGEN 000460-19-5
NOAEL 21.6 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 4E-2 IRIS 010263
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT. THE CHRONIC ORAL RfD
WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CYANOGEN BROMIDE 000506-68-3
NOAEL 44 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 9E-2 IRIS 010264
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CYCLOATE 001134-23-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005886
CYCLOHEXANOL 000108-93-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005887
CYCLOHEXYLAMINE 000108-91-8
IRIS 005400
NOAEL 30 MG/KG/DAY RAT
ORAL: DIET 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN 3E-1 005398
TESTIS DECREASED WEIGHT 100
CYCLOPENTADIENE 000542-92-7
010494
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DACTHAL 001861-32-1
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LUNG EFFECTS 1E-2 IRIS 005888
LIVER EFFECTS 100
KIDNEY EFFECTS
THYROID EFFECTS
THYROID EFFECTS
HORMONES
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DALAPON 000075-99-0
NOEL 8.45 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY INCREASED RELATIVE WEIGHT 3E-2 IRIS 005889
300
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO DALAPON SODIUM BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DDT 000050-29-3
NOEL 0.05 MG/KG/DAY RAT
ORAL: DIET 27 WEEKS LIVER LESIONS 5E-4 IRIS 005408
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DECABROMODIPHENYL ETHER 001163-19-5
NOEL 1 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER INCREASED WEIGHT 1E-2 IRIS 005891
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DI-N-OCTYL PHTHALATE 000117-84-0
LOAEL 175 MG/KG/DAY RAT
ORAL: DIET 7-12 MONTHS KIDNEY INCREASED WEIGHT 2E-2 2E-2 010275
LIVER INCREASED WEIGHT 1000 1000
LIVER INCREASED SGOT ACTIVITY
LIVER INCREASED SGPT ACTIVITY
DIAZINON 000333-41-5
NOAEL 0.09 MG/KG/DAY RAT
ORAL: DIET 35-42 DAYS BLOOD DECREASED CHOLINESTERASE 9E-4 9E-4 005892
ACTIVITY 100 100
DIBENZOFURAN 000132-64-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005409
DIBROMOBENZENE, 1,4- 000106-37-6
NOAEL 10 MG/KG/DAY RAT
ORAL: GAVAGE 45 OR 90 LIVER INCREASED RELATIVE WEIGHT 1E-1 IRIS 005893
DAYS LIVER ALTERED ENZYME ACTIVITIES 100
DIBROMOCHLOROMETHANE 000124-48-1
NOEL 21.4 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER LESIONS 2E-1 IRIS 005894
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIBROMOETHANE, 1,2- 000106-93-4
LOAEL 88 PPB HUMAN
INHALATION: SPERM EFFECTS 2E-3 2E-4 010854
INTERMITTENT 100 1000
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIBUTYL PHTHALATE 000084-74-2
NOAEL 125 MG/KG/DAY RAT
ORAL: DIET 52 WEEKS WHOLE BODY INCREASED MORTALITY 1E+0 IRIS 005622
100
IRIS 010892
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP.
DICAMBA 001918-00-9
NOAEL 3 MG/KG/DAY RABBIT
ORAL: GAVAGE GESTATION FETUS DECREASED WEIGHT 3E-2 IRIS 010945
DAYS 6-18 FETUS INCREASED POST-IMPLANTATION 100
LOSSES
FETUS INCREASED MORTALITY
DAM DECREASED WEIGHT GAIN
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DICHLOROBENZENE, 1,2- 000095-50-1
IRIS 010864
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DICHLOROBENZENE, 1,3- 000541-73-1
005414
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (06/23/92) BY THE RfD/RfC WORK GROUP.
DICHLOROBENZENE, 1,4- 000106-46-7
NOAEL 75 MG/CU M RAT
INHALATION: MULTI-GENERA LIVER INCREASED WEIGHT IN MALE 2.5E+0 IRIS 010840
INTERMITTENT TION PARENTS 30
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS MODIFIED TO ESTIMATE THE SUBCHRONIC INHALATION [RfC].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROBUTENES
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005415
DICHLORODIFLUOROMETHANE 000075-71-8
IRIS 005498
NOAEL 90 MG/KG/DAY DOG
ORAL: DIET 90 DAYS NONE OBSERVED 9E-1 005496
100
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
DICHLOROETHANE, 1,1- 000075-34-3
NOEL 115 MG/KG/DAY RAT
INHALATION: 13 WEEKS NONE OBSERVED 1E+0 1E-1 005790
INTERMITTENT 100 1000
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROETHYLENE, 1,1- 000075-35-4
LOAEL 9 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS LIVER LESIONS 9E-3 IRIS 005419
WATER 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROETHYLENE, 1,2- (MIXED ISOMERS) 000540-59-0
LOAEL 50 PPM RAT
ORAL: DRINKING 2 YEARS LIVER LESIONS 9E-3 9E-3 010509
WATER 1000 1000
SUBCHRONIC [RfD] COMMENT: VALUES DERIVED FOR 1,1-DICHLOROETHYLENE WERE ADOPTED FOR 1,2- DICHLOROETHYLENE MIXED ISOMERS
BASED ON ANALOGY.
CHRONIC [RfD] COMMENT: VALUES DERIVED FOR 1,1-DICHLOROETHYLENE (000075-35-4) WERE ADOPTED FOR 1,2-DICHLOROETHYLENE MIXED
ISOMERS BASED ON ANALOGY.
DICHLOROETHYLENE, 1,2-C- 000156-59-2
NOAEL 32 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS BLOOD DECREASED HEMATOCRIT 1E-1 1E-2 005420
BLOOD DECREASED HEMOGLOBIN 300 3000
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
DICHLOROETHYLENE, 1,2-T- 000156-60-5
NOAEL 17 MG/KG/DAY MOUSE
ORAL: DRINKING 90 DAYS BLOOD INCREASED ALKALINE PHOSPHATASE 2E-1 IRIS 005895
WATER 100
DICHLOROPHENOL, 2,3- 000576-24-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005315
DICHLOROPHENOL, 2,4- 000120-83-2
NOEL 3 PPM RAT
ORAL: DRINKING 2 IMMUNE SYSTEM ALTERED IMMUNE FUNCTION 3E-3 IRIS 005314
WATER GENERATIONS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A 2-GENERATION REPRODUCTION STUDY WITH EXPOSURES BEFORE AND DURING GESTATION,
PARTURITION, AND WEANING OF PUPS.
DICHLOROPHENOL, 2,5- 000583-78-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005316
DICHLOROPHENOL, 2,6- 000087-65-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005317
DICHLOROPHENOL, 3,4- 000095-77-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005318
DICHLOROPHENOL, 3,5- 000591-35-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005319
DICHLOROPHENOXY ACETIC ACID, 2,4- 000094-75-7
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 91 DAYS BLOOD TOXICITY 1E-2 IRIS 010265
LIVER TOXICITY 100
KIDNEY TOXICITY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DICHLOROPHENOXY) BUTYRIC ACID, 4-(2,4- / (2,4-DB) 000094-82-6
NOAEL 8 MG/KG/DAY DOG
ORAL: DIET 90 DAYS CARDIOVASCULAR HEMORRHAGE 8E-2 IRIS 005890
SYSTEM 100
WHOLE BODY INCREASED MORTALITY
DICHLOROPROPANE, 1,1- 000078-99-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005897
DICHLOROPROPANE, 1,2- 000078-87-5
NOAEL 69.3 MG/CU RAT
INHALATION: 13 WEEKS NASAL MUCOSA HYPERPLASIA 1.3E-2 IRIS 005898
INTERMITTENT 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DICHLOROPROPANE, 1,3- 000142-28-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005899
DICHLOROPROPANE, 2,2- 000594-20-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005900
DICHLOROPROPENE, 1,3- / (TELONE II) 000542-75-6
NOEL 3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS ORGANS INCREASED WEIGHT 3E-3 IRIS 005901
1000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
NOAEL 5 PPM MOUSE
INHALATION: 2 YEARS NASAL MUCOSA HYPERTROPHY 2E-2 IRIS 010351
INTERMITTENT NASAL MUCOSA HYPERPLASIA 30
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
DICHLORPROP 000120-36-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005896
DICYCLOPENTADIENE 000077-73-6
NOEL 32 MG/KG/DAY RAT
ORAL: DIET 3 NONE OBSERVED 3E-1 3E-2 005425
GENERATIONS 100 1000
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
DIELDRIN 000060-57-1
NOAEL 0.005 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER LESIONS 5E-5 IRIS 005429
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DIETHYL PHTHALATE 000084-66-2
NOAEL 750 MG/KG/DAY RAT
ORAL: DIET 16 WEEKS WHOLE BODY DECREASED GROWTH 8E+0 IRIS 005620
ORGANS DECREASED WEIGHT 100
DIETHYL-P-NITROPHENYL PHOSPHATE 000311-45-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005922
DIETHYLANILINE, N,N- 000091-66-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005903
DIETHYLENE GLYCOL MONOBUTYL ETHER 000112-34-5
NOAEL 18 PPM RAT
NONE OBSERVED 2E-1 2E-2 005482
100 1000
CHRONIC [RfC] COMMENT: UNDER REVIEW.
DIETHYLENE GLYCOL MONOETHYL ETHER 000111-90-0
NOEL 200 MG/KG/DAY RAT
ORAL: DRINKING KIDNEY HISTOPATHOLOGY 2E+O 005478
WATER 100
CHRONIC [RfD] COMMENT: BASED ON A 3-GENERATION REPRODUCTION STUDY.
NOEL 500 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY IMPAIRED FUNCTION 5E+0 005476
TESTIS INCREASED WEIGHT 100
DIETHYLFORMAMIDE 000617-84-5
NOEL 0.546 MG/DAY, 5 DAYS/WEEK RAT
ORAL: GAVAGE 73 WEEKS NONE OBSERVED 1.1E-2 1.1E-2 010437
100 100
DIETHYLHYDRAZINE, 1,2- 001615-80-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY. 005921
DIMETHOATE 000060-51-5
NOEL 0.05 MG/KG/DAY RAT
ORAL: DIET 2 YEARS BRAIN DECREASED CHOLINESTERASE 2E-4 IRIS 005923
ACTIVITY 300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DIMETHYLANILINE, N,N- 000121-69-7
LOAEL 22.32 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WEEKS SPLEEN EFFECTS 2E-2 IRIS 005924
1000
DIMETHYLFORMAMIDE, N,N- 000068-12-2
NOAEL 96 MG/KG/DAY RAT
ORAL: DIET 119 DAYS LIVER EFFECTS 1E+0 1E-1 005925
100 1000
LOAEL 22 MG/CU M HUMAN
INHALATION: LIVER EFFECTS 3E-2 IRIS 010352
INTERMITTENT GASTRO EFFECTS 300
INTESTINAL SYSTEM
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RFC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RFC].
DIMETHYLPHENOL, 2,3- 000526-75-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005926
DIMETHYLPHENOL, 2,4- 000105-67-9
NOAEL 50 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS NERVOUS SYSTEM EFFECTS 2E-1 IRIS 010266
BLOOD ALTERATIONS 300
DIMETHYLPHENOL, 2,5- 000095-87-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005928
DIMETHYLPHENOL, 2,6- 000576-26-1
NOEL 0.6 MG/KG/DAY RAT
ORAL 8 MONTHS WHOLE BODY INCREASED WEIGHT 6E-3 IRIS 005431
ORGANS, MAJOR LESIONS 100
DIMETHYLPHENOL, 3,4- 000095-65-8
NOEL 1.4 MG/KG/DAY RAT
ORAL 8 MONTHS WHOLE BODY DECREASED WEIGHT 1E-2 IRIS 005437
ORGANS, MAJOR LESIONS 100
CARDIOVASCULAR ALTERED BLOOD PRESSURE
SYSTEM
DIMETHYLPHTHALATE 000131-11-3
CHRONIC RfD COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (02/16/94) BY THE RfD/RfC WORK GROUP. 010267
IRIS 010894
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (07/26/90) BY THE RfD/RfC WORK GROUP.
DIMETHYLTEREPHTHALATE 000120-61-6
LOAEL 125 MG/KG/DAY RAT
ORAL: DIET 103 WEEKS KIDNEY INFLAMMATION 1E-1 IRIS 005930
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DIMETHYLUREA, N,N- 000598-94-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005931
DINITRO-O-CRESOL, 4,6- 000534-52-1
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (02/11/93) BY THE RfD/RfC WORK GROUP. 010470
DINITRO-P-CRESOL, 2,6- 000609-93-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005934
DINITROBENZENE, 1,2- 000528-29-0
NOAEL 0.4 MG/KG/DAY RAT
ORAL: DRINKING 16 WEEKS SPLEEN INCREASED WEIGHT 4E-3 4E-4 010201
WATER 100 1000
SUBCHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
DINITROBENZENE, 1,3- 000099-65-0
NOAEL 0.4 MG/KG/DAY RAT
ORAL: DRINKING SPLEEN INCREASED WEIGHT 1E-3 IRIS 010471
WATER 100
DINITROBENZENE, 1,4- 000100-25-4
NOAEL 0.4 MG/KG/DAY RAT
ORAL: DRINKING 16 WEEKS SPLEEN INCREASED WEIGHT 4E-3 4E-4 010202
WATER 100 1000
SUBCHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT: DERIVED BY ANALOGY TO 1,3-DINITROBENZENE.
DINITROPHENOL, 2,3- 000066-56-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005936
DINITROPHENOL, 2,4- 000051-28-5
LOAEL 2 MG/KG/DAY HUMAN
ORAL EYE CATARACT 2E-3 IRIS 010438
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 010895
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (06/13/91) BY THE RfD/RfC WORK GROUP.
DINITROPHENOL, 2,5- 000329-71-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005937
DINITROPHENOL, 2,6- 000573-56-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005938
DINITROPHENOL, 3,5- 000586-11-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005939
DINITROTOLUENE, 2,3- 000602-01-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005940
DINITROTOLUENE, 2,4- 000121-14-2
NOAEL 0.2 MG/KG/DAY DOG
ORAL: GELATIN UP TO 2 CENTRAL NERVOUS NEUROTOXICITY 2E-3 IRIS 005941
CAPSULE YEARS SYSTEM 100
ERYTHROCYTES HEINZ BODIES
BILIARY TRACT HYPERPLASIA
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD IS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010896
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/20/90) BY THE RfD/RfC WORK GROUP.
DINITROTOLUENE, 2,5- 000619-15-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005942
DINITROTOLUENE, 2,6- 000606-20-2
NOAEL 4 MG/KG/DAY DOG
ORAL: DIET 13 WEEKS WHOLE BODY MORTALITY 1E-2 1E-3 005943
CENTRAL NERVOUS NEUROTOXICITY 300 3000
SYSTEM
BLOOD HEINZ BODIES
BLOOD METHEMOGLOBINEMIA
BILE DUCT HYPERPLASIA
KIDNEY HISTOPATHOLOGY
CHRONIC [RfD] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
DINITROTOLUENE, 3,4- 000610-39-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005944
DINOSEB 000088-85-7
LOAEL 1 MG/KG/DAY RAT
ORAL: DIET 29 WEEKS FETUS DECREASED WEIGHT 1E-3 IRIS 005945
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RFD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RFD WAS DETERMINED FROM A 3-GENERATION REPRODUCTION STUDY.
DIPHENYLAMINE, N,N- 000122-39-4
NOEL 2.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 2.5E-2 IRIS 005946
LIVER INCREASED WEIGHT 100
KIDNEY INCREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
DIRECT LIGHTFAST BLUE 004399-55-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005947
DISULFOTON 000298-04-4
LOAEL 0.04 MG/KG/DAY RAT
ORAL: DIET 2 YEARS EYE DEGENERATION 4E-5 IRIS 010412
BLOOD CHOLINESTERASE INHIBITION 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
ENDOSULFAN 000115-29-7
NOAEL 15 PPM RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 6E-3 IRIS 010926
KIDNEY GLOMERULONEPHROSIS 100
BLOOD VESSEL ANEURYSMS
NOAEL 10 PPM DOG
ORAL: DIET 1 YEAR WHOLE BODY DECREASED WEIGHT GAIN 010938
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHORNIC ORAL [RfD]. BASED ON CO-CRITICAL RAT AND DOG
STUDIES.
ENDOTHALL 000145-73-3
NOEL 2 MG/KG/DAY DOG
ORAL: DIET 2 YEARS STOMACH INCREASED WEIGHT 2E-2 IRIS 005948
SMALL INTESTINE INCREASED WEIGHT 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
ENDRIN 000072-20-8
NOEL 0.025 MG/KG/DAY DOG
ORAL: DIET 2 YEARS CENTRAL NERVOUS CONVULSIONS 3E-4 IRIS 005445
SYSTEM 100
LIVER LESIONS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
EPICHLOROHYDRIN 000106-89-8
LOAEL 37.8 MG/CU M RAT
INHALATION: 136 WEEKS KIDNEY LESIONS 2E-3 2E-3 010440
INTERMITTENT 1000 1000
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE-TO-ROUTE EXTRAPOLATION. THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (04/01/92).
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
NOAEL 19 MG/CU M RAT
INHALATION: 90 DAYS NASAL LESIONS 1E-2 IRIS 010492
INTERMITTENT EPITHELIUM 100
EPTC 000759-94-4
NOEL 2.5 MG/KG/DAY RAT
ORAL: DIET 2 HEART DEGENERATIVE CARDIOMYOPATHY 2.5E-2 IRIS 005959
GENERATIONS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RFD WAS DETERMINED FROM A 2-GENERATION REPRODUCTION STUDY.
ETHOPROP 013194-48-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005951
ETHOXYETHANOL ACETATE, 2- 000111-15-9
010507
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
ETHOXYETHANOL ACRYLATE, 2- 000106-74-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005953
ETHOXYETHANOL DODECANOATE, 2- 000106-13-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005956
ETHOXYETHANOL PHOSPHATE, 2- 068554-00-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005955
ETHOXYETHANOL, 2- 000110-80-5
LOAEL 357 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS WHOLE BODY DECREASED WEIGHT 4E-1 005470
1000
NOEL 50 uL/KG/DAY RAT
ORAL: GAVAGE 21 DAYS FETUS SKELETAL MALFORMATIONS 5E-1 005468
100
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 1-21 OF GESTATION.
NOAEL 380 MG/CU M RABBIT
INHALATION: 13 WEEKS BLOOD ALTERED HEMATOLOGY 2E+0 IRIS 010441
INTERMITTENT 30
ETHOXYETHYL METHACRYLATE, 2- 002370-63-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005954
ETHYL ACETATE 000141-78-6
NOEL 900 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS WHOLE BODY INCREASED MORTALITY 9E+0 IRIS 005957
WHOLE BODY DECREASED WEIGHT 100
ETHYL BENZENE 000100-41-4
IRIS 010867
IRIS 010866
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
ETHYL CHLORIDE 000075-00-3
NOAEL 1504 PPM MOUSE
INHALATION: 10 DAYS FETUS DEVELOPMENTAL TOXICITY 1E+1 IRIS 010371
INTERMITTENT 300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
CHRONIC [RfC] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYL ETHER 000060-29-7
NOAEL 500 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER EFFECTS 2E+0 IRIS 010396
300
ETHYL METHACRYLATE 000097-63-2
NOEL 7.5 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS KIDNEY INCREASED RELATIVE WEIGHT 9E-2 9E-2 005961
WATER 100 100
CHRONIC [RfD] COMMENT: CALCULATED FROM METHYL METHACRYLATE DATA BY MULTIPLYING BY THE RATIO OF THE MOLECULAR WEIGHTS (114.5/100.13).
ETHYL-O-XYLENE, 4- 000934-80-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 010472
ETHYLANILINE, N- 000103-69-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005958
ETHYLENE CYANOHYDRIN 000109-78-4
NOEL 30 MG/KG/DAY RAT
ORAL: DRINKING 90 DAYS HEART DECREASED WEIGHT 3E-1 3E-1 005780
WATER BRAIN DECREASED WEIGHT 100 100
ETHYLENE DIAMINE 000107-15-3
NOAEL 22.6 MG/KG/DAY RAT
ORAL: DIET 3 MONTHS HEART DECREASED WEIGHT 2E-1 2E-2 005796
BLOOD HEMATOLOGIC CHANGES 100 1000
IRIS 010898
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90) BY THE RfD/RfC WORK GROUP.
ETHYLENE GLYCOL 000107-21-1
IRIS 005454
NOEL 200 MG/KG/DAY RAT
ORAL: DIET FETUS FETOTOXICITY 2E+0 005452
100
SUBCHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
ETHYLENE GLYCOL MONOBUTYL ETHER 000111-76-2
NOAEL 121 MG/CU M RAT
INHALATION: 13 WEEKS BLOOD ALTERED HEMATOLOGY 2E-1 2E-2 010353
INTERMITTENT 100 1000
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
ETHYLENE THIOUREA 000096-45-7
LOAEL 0.25 MG/KG/DAY RAT
ORAL: DIET 24 MONTHS THYROID HYPERPLASIA 8E-5 IRIS 010397
3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010899
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/12/92) BY THE RfD/RfC WORK GROUP.
ETHYLTOLUENE, M- 000620-14-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005963
ETHYLTOLUENE, O- 000611-14-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005962
ETHYLTOLUENE, P- 000622-96-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005964
FLUORANTHENE 000206-44-0
NOAEL 125 MG/KG/DAY MOUSE
ORAL: GAVAGE 90 DAYS KIDNEY NEPHROPATHY 4E-1 IRIS 010168
LIVER WEIGHT CHANGES 300
BLOOD HEMATOLOGICAL CHANGES
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP. 010967
FLUORENE 000086-73-7
NOAEL 125 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WEEKS ERYTHROCYTES DECREASED COUNTS 4E-1 IRIS 010169
300
FLUORINE / (SOLUBLE FLUORIDE) 007782-41-4
NOAEL 0.06 MG/KG/DAY HUMAN
ORAL: DRINKING TOOTH FLUOROSIS 6E-2 IRIS 005965
WATER 1
FLURIDONE 059756-60-4
NOEL 200 PPM RAT
ORAL: DIET 2 YEARS KIDNEY GLOMERULONEPHRITIS 8E-2 IRIS 005966
TESTIS ATROPHY 100
WHOLE BODY DECREASED WEIGHT
ORGANS DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
FOLPET 000133-07-3
NOEL 10 MG/KG/DAY DOG
ORAL: CAPSULE 1 YEAR WHOLE BODY ALTERED WEIGHT GAIN 1E-1 IRIS 005967
BLOOD ALTERED CHEMISTRY 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE 000050-00-0
NOAEL 15 MG/KG/DAY RAT
ORAL: WATER 2 YEARS GASTRO- LESIONS 2E-1 IRIS 010398
INTESTINAL TRACT 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
FORMALDEHYDE CYANOHYDRIN 000107-16-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005782
FORMIC ACID 000064-18-6
NOAEL 200 MG/KG/DAY RAT
ORAL: WATER MULTI- WHOLE BODY DECREASED GROWTH 2E+0 2E+0 010268
GENERATION 100 100
CHRONIC [RfD] COMMENT: BASED ON A MULTI-GENERATION STUDY. WITHDRAWN FROM IRIS (12/01/90). UNDER REVIEW,
CURRENT NUMBER SUBJECT TO CHANGE.
FURAN 000110-00-9
NOAEL 1.4 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WEEKS LIVER LESIONS 1E-2 IRIS 005462
100
FURFURAL 000098-01-1
LOAEL 7.9 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER HEPATOTOXICITY 3E-2 IRIS 005466
300
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GLYCIDALDEHYDE 000765-34-4
NOAEL 29 MG/CU M RAT
INHALATION: 12 WEEKS WHOLE BODY DECREASED WEIGHT 1E-2 4E-3 1E-3 IRIS 005968
INTERMITTENT KIDNEY EFFECTS 300 300 3000
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEPTACHLOR 000076-44-8
NOEL 0.15 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER INCREASED WEIGHT 5E-4 IRIS 005506
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
HEPTACHLOR EPOXIDE 001024-57-3
LOAEL 0.0125 MG/KG/DAY DOG
ORAL: DIET 60 WEEKS LIVER INCREASED RELATIVE WEIGHT 1.3E-5 IRIS 010399
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEPTANE, N- 000142-82-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005969
HEXABROMOBENZENE 000087-82-1
NOAEL 2 MG/KG/DAY RAT
ORAL: DIET 12 WEEKS LIVER INDUCED CARBOXYLESTERASE 2E-2 IRIS 005970
ACTIVITY 100
HEXACHLOROBENZENE 000118-74-1
IRIS 010868
IRIS 010900
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP.
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
HEXACHLOROBUTADIENE 000087-68-3
LOAEL 0.5 MG/KG/DAY MOUSE
ORAL: DIET 13 WEEKS RENAL TUBULES REGENERATION 2E-4 010927
1000
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (05/01/93). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
HEXACHLOROCYCLOHEXANE, DELTA- 000319-86-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY. 010495
HEXACHLOROCYCLOHEXANE, EPSILON- 006108-10-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY. 010496
HEXACHLOROCYCLOHEXANE, GAMMA- 000058-89-9
NOAEL 0.33 MG/KG/DAY RAT
ORAL: DIET 12 WEEKS LIVER TOXICITY 3E-3 IRIS 005537
KIDNEY TOXICITY 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010903
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (05/27/92) BY THE RfD/RfC WORK GROUP.
HEXACHLOROCYCLOPENTADIENE 000077-47-4
NOAEL 7.1 MG/KG/DAY RAT
ORAL 13 WEEKS FORESTOMACH LESIONS 7E-2 IRIS 005299
100
NOAEL 0.15 PPM RAT
INHALATION: 13 WEEKS NASAL CAVITY SQUAMOUS METAPLASIA 7E-4 7E-5 010445
INTERMITTENT 100 1000
HEXACHLOROETHANE 000067-72-1
NOAEL 1 MG/KG/DAY RAT
ORAL: DIET 16 WEEKS KIDNEY DEGENERATION 1E-2 IRIS 005518
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
010904
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (11/05/92), BY THE RfD/RfC WORK GROUP.
HEXACHLOROPHENE 000070-30-4
LOAEL 0.75 MG/KG/DAY DOG
ORAL: DIET 13 WEEKS NERVOUS SYSTEM EFFECTS 3E-3 IRIS 005972
300
HEXAMETHYLENE DIAMINE 000124-09-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005973
HEXANE, N- 000110-54-3
LOAEL 570 MG/KG/DAY RAT
ORAL NERVOUS SYSTEM NEUROPATHY 6E-1 6E-2 005974
TESTIS ATROPHY 1000 10000
LOAEL 73 MG/CU M HUMAN
INHALATION: NERVOUS SYSTEM NEUROTOXICITY 2E-1 IRIS 010273
INTERMITTENT 300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
HEXANONE, 2- 000591-78-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005976
HYDROGEN SULFIDE 007783-06-4
NOAEL 3.1 MG/KG/DAY PIG
ORAL: FOOD 105 DAYS GASTRO- DISTURBANCE 3E-2 IRIS 010269
INTESTINAL SYSTEM 10O
NOAEL 42 MG/CU M MOUSE
INHALATION: 13 WEEKS NASAL MUCOSA INFLAMMATION 1E-2 IRIS 010354
INTERMITTENT 100
HYDROQUINONE 000123-31-9
NOAEL 4.29 MG/KG/DAY HUMAN
ORAL 3-5 MONTHS BLOOD HEMATOLOGICAL EFFECTS 4E-1 4E-2 005526
10 100
IRIS 010905
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
IRON 007439-89-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005527
ISOBUTYL ALCOHOL 000078-83-1
NOEL 316 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS NERVOUS SYSTEM HYPOACTIVITY 3E+0 IRIS 005977
NERVOUS SYSTEM ATAXIA 100
ISOPHORONE 000078-59-1
NOEL 150 MG/KG/DAY DOG
ORAL: CAPSULE 90 DAYS KIDNEY LESIONS 2E+0 IRIS 005910
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
IRIS 010906
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/15/90) BY THE RfD/RfC WORK GROUP.
ISOPROPALIN 033820-53-0
NOEL 15 MG/KG/DAY RAT
ORAL: DIET 90 DAYS BLOOD HEMATOLIGICAL EFFECTS 1.5E-1 IRIS 005978
ORGANS, ALTERED WEIGHTS 100
UNSPECIFIED
LACTONITRILE 000078-97-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005783
LEAD 007439-92-1
010447
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT: REFER TO IRIS
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
LEAD ALKYLS
010448
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS.
CHRONIC [RfD] COMMENT: REFER TO IRIS
GENERAL COMMENT: DIMETHYLETHYL LEAD; METHYLTRIETHYL LEAD; TETRABUTYL LEAD; TETRAETHYL LEAD; TETRAMETHYL LEAD;
TETRAPROPYL LEAD; TRIETHYL LEAD; TRIMETHYL LEAD; TRIMETHYLETHYL LEAD; TRIPROPYL LEAD
LINURON 000330-55-2
LOAEL 0.625 MG/KG/DAY DOG
ORAL: DIET 2 YEARS BLOOD HEMATOLOGICAL EFFECTS 2E-3 IRIS 005990
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
MALATHION 000121-75-5
NOEL 0.23 MG/KG/DAY HUMAN
ORAL: CAPSULE 47 DAYS BLOOD HEMATOLOGICAL EFFECTS 2E-2 IRIS 005991
10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfC] COMMENT: UNDER REVIEW.
MALEIC ANHYDRIDE 000108-31-6
NOAEL 10 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY LESIONS 1E-1 IRIS 005992
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
MALEIC HYDRAZIDE 000123-33-1
LOAEL 500 MG/KG/DAY RAT
ORAL: DIET 28 MONTHS KIDNEY ALTERED FUNCTION 5E-1 IRIS 005993
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
MALONONITRILE 000109-77-3
LOAEL 0.21 MG/KG/DAY RAT
ORAL: GAVAGE 120 DAYS LIVER EFFECTS 2E-4 2E-5 005994
SPLEEN EFFECTS 1000 10000
MANCOZEB 008018-01-7
NOEL 2.9 MG/KG/DAY RAT
ORAL: DIET 90 WEEKS THYROID GOITROGENIC EFFECTS 3E-2 3E-2 005995
100 100
MANEB 012427-38-2
NOEL 5 MG/KG/DAY MONKEY
ORAL: DIET 6 MONTHS THYROID INCREASED WEIGHT 5E-2 IRIS 005996
100
MANGANESE 007439-96-5
NOAEL 0.14 MG/KG/DAY HUMAN
ORAL: DIET CHRONIC CENTRAL NERVOUS EFFECTS 1.4E-1 IRIS 010851
SYSTEM 1
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL FOOD RfD WAS ADOPTED AS THE SUBCHRONIC ORAL FOOD [RfD].
SEE IRIS FOR SPECIFIC DIETARY INFORMATION.
IRIS 010959
SUBCHRONIC [RfC] COMMENT: A SUBCHRONIC [RfC] HAS NOT BEEN DERIVED FOR MANGANESE.
MEPHOSFOLAN 000950-10-7
NOEL 0.09 MG/KG/DAY RAT
ORAL: DIET 17 WEEKS LIVER ALTERED WEIGHT 9E-4 9E-5 005997
KIDNEY ALTERED WEIGHT 100 1000
BLOOD DECREASED CHOLINESTERASE
ACTIVITY
ERYTHROCYTES DECREASED CHOLINESTERASE
ACTIVITY
BRAIN DECREASED CHOLINESTERASE
ACTIVITY
MERCURIC CHLORIDE 007487-94-7
RAT
ORAL; SUBCUTANEOUS IMMUNE SYSTEM AUTOIMMUNE EFFECTS 3E-3 IRIS 005800
100
MERCURY, ELEMENTAL 007439-97-6
NOAEL 0.009 MG/CU M HUMAN
INHALATION: NERVOUS SYSTEM NEUROTOXICITY 3E-4 3E-4 010270
30 30
CHRONIC [RfC] COMMENT: UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
MERPHOS 000150-50-5
NOEL 0.1 MG/KG/DAY HEN
ORAL: CAPSULE 3 MONTHS NERVOUS SYSTEM ATAXIA 3E-4 IRIS 005998
NERVOUS SYSTEM DELAYED NEUROTOXICITY 300
WHOLE BODY DECREASED WEIGHT
010907
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
MERPHOS OXIDE 000078-48-8
NOEL 0.1 MG/KG/DAY HEN
ORAL: CAPSULE 3 MONTHS NERVOUS SYSTEM ATAXIA 3E-4 IRIS 005999
NERVOUS SYSTEM DELAYED NEUROTOXICITY 300
WHOLE BODY DECREASED WEIGHT
010908
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (06/25/92) BY THE RfD/RfC WORK GROUP.
SUBCHRONIC [RfD] CPMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
METHACRYLONITRILE 000126-98-7
NOAEL 3.2 PPM DOG
INHALATION: 90 DAYS LIVER INCREASED SGOT 1E-3 IRIS 005812
INTERMITTENT LIVER INCREASED SGPT 300
CENTRAL NERVOUS LOSS OF HINDLIMB MOTOR CONTROL
SYSTEM
BRAIN LESIONS
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
METHANOL 000067-56-1
NOEL 500 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS BLOOD INCREASED ALKALINE PHOSPHATASE 5E+0 IRIS 010271
BLOOD INCREASED SGPT 10O
BRAIN DECREASED WEIGHT
METHOMYL 016752-77-5
NOEL 2.5 MG/KG/DAY DOG
ORAL: DIET 24 MONTHS KIDNEY LESIONS 2.5E-2 IRIS 005802
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHOXYCHLOR 000072-43-5
NOEL 5.01 MG/KG/DAY RABBIT
ORAL: GAVAGE 13 DAYS REPRODUCTION LOSS OF LITTERS 5E-3 IRIS 010357
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
IRIS 010909
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (11/07/91) BY THE RfD/RfC WORK GROUP.
METHOXYETHANOL ACETATE, 2- 000110-49-6
010497
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHOXYETHANOL, 2- 000109-86-4
NOAEL 93 MG/CU M RABBIT
INHALATION: 13 WEEKS TESTICLE EFFECTS 2E-1 IRIS 010372
INTERMITTENT 100
SUBCHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
METHYL ACETATE 000079-20-9
NOEL 1156 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER INCREASED ALKALINE PHOSPHATASE 1E+1 1E+0 010002
LIVER INCREASED SGPT 100 1000
CHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH METHANOL BY MULTIPLYING BY THE MOLECULAR WEIGHT RATIO (74.08/32.04).
METHYL ACRYLATE 000096-33-3
010498
CHRONIC [RfD] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL CHLOROCARBONATE 000079-22-1
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (05/01/89).
GENERAL COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
METHYL ETHYL KETONE 000078-93-3
NOAEL 1711 MG/KG/DAY RAT
ORAL: DRINKING MULTI- FETUS DECREASED BIRTH WEIGHT 2E+0 IRIS 010853
WATER GENERATION 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS MODIFIED TO ESTIMATE THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: MULTI-GENERATION DEVELOPMENTAL STUDY PERFORMED WHT THE SURROGATE 2-BUTANOL, A METABOLITE OF METHYL ETHYL KETONE.
NOAEL 1010 PPM MOUSE
INHALATION: 10 DAYS FETUS DECREASED BIRTH WEIGHT 1E+0 IRIS 010845
INTERMITTENT 3000
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
METHYL ETHYL KETONE PEROXIDE 001338-23-4
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP. 010948
METHYL ISOBUTYL KETONE 000108-10-1
NOAEL 250 MG/(KG-DAY) RAT
ORAL: GAVAGE 13 WEEKS WHOLE BODY LETHARGY 8E-1 8E-2 010949
LIVER INCREASED RELATIVE WEIGHT IN 300 3000
FEMALES
LIVER INCREASED ABSOLUTE WEIGHT IN
FEMALES
KIDNEY INCREASED RELATIVE WEIGHT IN
FEMALES
KIDNEY INCREASED ABSOLUTE WEIGHT IN
FEMALES
KIDNEY INCREASED URINARY PROTEIN
LEVELS IN FEMALES
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (03/01/91), UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
METHYL ISOCYANATE 000624-83-9
IRIS 010013
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (12/18/90) BY THE RfD/RfC WORK GROUP.
METHYLMERCURY 022967-92-6
CRITICAL ORAL DOSE HUMAN
0.001 MG/KG/DAY DEVELOPMENTAL NEUROLOGICAL ABNORMALITIES 1E-4 IRIS 010970
IN HUMAN INFANTS 10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: A BENCHMARK DOSE APPROACH WAS USED RATHER THAN A NOAEL/LOAEL TO DERIVE THE RfD.
METHYL METHACRYLATE 000080-62-6
NOEL 7.5 MG/KG/DAY RAT
ORAL: WATER 24 MONTHS KIDNEY INCREASED RELATIVE WEIGHT 8E-2 8E-2 010014
100 100
METHYL PARATHION 000298-00-0
IRIS 010015
NOAEL 2.5 PPM RAT
ORAL: DIET 90 DAYS ERYTHROCYTES CHOLINESTERASE INHIBITION 2E-3 010846
100
METHYL STYRENE (MIXED ISOMERS) 025013-15-4
010500
CHRONIC [RfD] COMMENT: UNDER REVIEW. ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY
(OTHER THAN CARCINOGENICITY)
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL STYRENE, ALPHA 000098-83-9
010499
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYL-4-CHLOROPHENOXY) BUTYRIC ACID, 4-(2- 000094-81-5
NOEL 12 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS LIVER EFFECTS 1E-1 IRIS 010008
KIDNEY EFFECTS 100
DOG
ORAL: DIET 13 WEEKS LIVER EFFECTS
KIDNEY EFFECTS
METHYL-4-CHLOROPHENOXY) PROPIONIC ACID, 2-(2- 000093-65-2
NOEL 3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY ALTERED WEIGHT 1E-2 IRIS 010009
300
METHYL-4-CHLOROPHENOXYACETIC ACID, 2- 000094-74-6
NOEL 0.15 MG/KG/DAY DOG
ORAL: DIET 52 WEEKS KIDNEY EFFECTS 5E-4 IRIS 010007
LIVER EFFECTS 300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
METHYLCYCLOHEXANE 000108-87-2
NOAEL 287 MG/CU M RAT
INHALATION: 1 YEAR KIDNEY MINERALIZATION 3E+0 3E+0 010431
INTERMITTENT KIDNEY PAPILLARY HYPERPLASIA 100 100
METHYLENE BROMIDE 000074-95-3
010501
GENERAL COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS -- SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
METHYLENE CHLORIDE (DICHLOROMETHANE) 000075-09-2
NOAEL 5.85 MG/KG/DAY RAT
ORAL: DRINKING 24 MONTHS LIVER TOXICITY 6E-2 IRIS 005553
WATER 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NOAEL 694.8 MG/CU M RAT
INHALATION: 2 YEARS LIVER TOXICITY 3E+0 3E+0 005552
INTERMITTENT 100 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
METHYLENE-BIS(2-CHLOROANILINE), 4,4'- 000101-14-4
LOAEL 7.3 MG/KG/DAY DOG
ORAL 9 YEARS LIVER EFFECTS 7E-4 7E-4 010413
BLADDER EFFECTS 10000 10000
010933
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE 02/10/93) BY THE RfD/RfC WORK GROUP.
METHYLENEDIPHENYL ISOCYANATE, 4,4- (DIPHENYLMETHANE DIISOCYANATE) 000101-68-8
NOAEL 0.2 MG/CU M RAT
INHALATION: 24 MONTHS NASAL CAVITY LESIONS 2E-5 IRIS 010449
INTERMITTENT 300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC ON IRIS WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
METOLACHLOR 051218-45-2
NOAEL 300 PPM RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 1.5E-1 1.5E-1 010950
100 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUCHRONIC ORAL [RfD].
METRIBUZIN 021087-64-9
NOAEL 100 PPM DOG
ORAL: DIET 2 YEARS LIVER EFFECTS IRIS 010928
KIDNEY EFFECTS
WHOLE BODY MORTALITY
WHOLE BODY DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: THE SUBCHRONIC ORAL [RfD] WAS REMOVED BECAUSE THE CHRONIC ORAL RfD UPON WHICH IT WAS BASED IS
UNDER REVIEW BY THE RfD/RfC WORK GROUP.
CHRONIC RfD COMMENT: THE CHRONIC ORAL RfD, WHILE STILL ON IRIS, IS BEING RECONSIDERED BY THE RfD/RfC WORK GROUP.
MIREX 002385-85-5
NOAEL 0.07 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER CYTOMEGALY 2E-4 IRIS 010841
LIVER FATTY METAMORPHOSIS 300
LIVER ANGIECTASIS
THYROID CYSTIC FOLLICLES
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
MOLINATE 002212-67-1
NOEL 0.2 MG/KG/DAY RAT
ORAL: GAVAGE REPRODUCTIVE TOXICITY 2E-3 IRIS 010017
SYSTEM 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A REPRODUCTION STUDY.
MOLYBDENUM 007439-98-7
LOAEL 0.14 MG/KG/DAY HUMAN
ORAL: WATER, URINE INCREASED URIC ACID 5E-3 IRIS 010489
DIET JOINTS PAIN, SWELLING 30
BLOOD DECREASED COPPER LEVELS
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RFD].
MONOCHLORAMINE 010599-90-3
NOAEL 9.5 MG/KG/DAY RAT
ORAL: DRINKING 2 YEARS WHOLE BODY WEIGHT CHANGES 1E-1 IRIS 010517
WATER LIVER WEIGHT CHANGES 100
KIDNEY WEIGHT CHANGES
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NAPHTHALENE 000091-20-3
CHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
NAPHTHOQUINONE, 1,4- 000130-15-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010020
NICKEL CYANIDE 000557-19-7
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/20/93) BY THE RfD/RfC WORK GROUP. 010953
NICKEL, SOLUBLE SALTS VARIOUS
NOAEL 100 PPM RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 2E-2 IRIS 005579
ORGANS, MAJOR DECREASED WEIGHT 300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS DERIVED FROM NICKEL MOIETY OF ADMINISTERED NICKEL CHLORIDE.
NICOTINONITRILE 000100-54-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005584
NITRIC OXIDE 010102-43-9
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010451
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS.
NITRITE 014797-65-0
NOEL 10 PPM HUMAN
ORAL: WATER BLOOD METHEMOGLOBINEMIA 1E-1 IRIS 010021
10
SUBCHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN
POPULATION (INFANTS). THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: THIS VALUE IS BASED ON NITRATE (NITROGEN) DATA FROM THE MOST SENSITIVE HUMAN POPULATION (INFANTS).
NITROANILINE, 2- 000088-74-4
010936
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RFD] IS CONSIDERED NOT VERIFIABLE (06/23/92) BY THE RFD/RFC WORK GROUP.
LOAEL 9.8 MG/CU M RAT
INHALATION: 4 WEEKS BLOOD HEMATOLOGICAL EFFECTS 2E-3 2E-4 010935
INTERMITTENT 1000 10000
NITROANILINE, M- 000099-09-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010400
NITROANILINE, P- 000100-01-6
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010024
NITROBENZENE 000098-95-3
LOAEL 25 MG/CU M MOUSE
INHALATION: 90 DAYS BLOOD HEMATOLOGICAL EFFECTS 5E-3 IRIS 005589
INTERMITTENT ADRENAL LESIONS 1000
KIDNEY LESIONS
LIVER LESIONS
RAT
INHALATION: 90 DAYS BLOOD HEMATOLOGICAL EFFECTS
INTERMITTENT ADRENAL LESIONS
KIDNEY LESIONS
LIVER LESIONS
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY).
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION.
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS SUBCHRONIC AND CHRONICTOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfD] COMMENT: THE ORAL RFD, WHILE STILL AVAILABLE ON IRIS, IS BEING RECONSIDERED BY THE RFD WORKGROUP. BASED ON ROUTE
TO ROUTE EXTRAPOLATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
NITROFURANTOIN 000067-20-9
NOAEL 300 PPM MOUSE
ORAL: DIET 13 WEEKS TESTIS DAMAGE 7E-1 7E-2 005593
100 1000
NITROGEN DIOXIDE 010102-44-0
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD HAS BEEN PERMANENTLY WITHDRAWN (09/01/94) FROM IRIS. 010402
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010912
NITROGEN OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010170
NITROMETHANE 000075-52-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010026
NITROPHENOLS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005594
NITROPROPANE, 2- 000079-46-9
LOAEL 78 MG/CU M RAT
INHALATION: 22 MONTHS LIVER LESIONS 2E-2 IRIS 010374
INTERMITTENT 1000
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
NITROSODIPHENYLAMINE, P- 000156-10-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010027
NITROTOLUENE, M- 000099-08-1
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS SPLEEN LESIONS 1E-1 1E-2 010029
1000 10000
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH O-NITROTOLUENE.
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH O-NITROTOLUENE.
NITROTOLUENE, O- 000088-72-2
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS SPLEEN LESIONS 1E-1 1E-2 010028
1000 10000
NITROTOLUENE, P- 000099-99-0
LOAEL 200 MG/KG/DAY RAT
ORAL: GAVAGE 6 MONTHS SPLEEN LESIONS 1E-1 1E-2 010030
1000 10000
SUBCHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH O-NITROTOLUENE.
CHRONIC [RfD] COMMENT: BASED ON DATA OBTAINED WITH O-NITROTOLUENE.
OCTABROMODIPHENYL ETHER 032536-52-0
NOAEL 2.5 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER HISTOLOGICAL CHANGES 3E-2 IRIS 010032
100
OCTAMETHYLPYROPHOSPHORAMIDE 000152-16-9
NOAEL 0.02 MG/KG/DAY HUMAN
ORAL AT LEAST 30 BLOOD DECREASED CHOLINESTERASE 2E-3 2E-3 010031
DAYS ACTIVITY 10 10
OSMIUM TETROXIDE 020816-12-0
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP. 010954
OZONE 010028-15-6
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010171
PARALDEHYDE 000123-63-7
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 010033
PARATHION 000056-38-2
NOAEL 0.064 MG/KG/DAY HUMAN
ORAL CHOLINESTERASE DECREASED CHOLINESTERASE 6E-3 6E-3 005598
ACTIVITY 10 10
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PARTICULATE MATTER
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010034
PEBULATE 001114-71-2
NOEL 5 MG/KG/DAY RAT
ORAL: DIET SUBCHRONIC BLOOD INCREASED CLOTTING TIME 5E-2 5E-2 010036
100 100
PENDIMETHALIN 040487-42-1
NOEL 12.5 MG/KG/DAY DOG
ORAL: CAPSULE 2 YEARS LIVER EFFECTS 4E-2 IRIS 010037
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PENTABROMODIPHENYL ETHER 032534-81-9
NOAEL 1.8 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER ALTERED ENZYME ACTIVITIES 2E-2 IRIS 010038
100
PENTACHLOROBENZENE 000608-93-5
LOAEL 8.3 MG/KG/DAY RAT
ORAL: DIET 100 DAYS LIVER TOXICITY 8E-3 IRIS 010039
KIDNEY TOXICITY 1000
PENTACHLOROCYCLOPENTADIENE 025329-35-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 005302
PENTACHLORONITROBENZENE 000082-68-8
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER TOXICITY 3E-3 IRIS 010040
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PENTACHLOROPHENOL 000087-86-5
NOEL 3 MG/KG/DAY RAT
ORAL: GAVAGE 62 DAYS FETUS FETOTOXICITY 3E-2 IRIS 005600
100
SUBCHRONIC [RfD] COMMENT: BASED ON A TERATOLOGY STUDY WITH EXPOSURE 62 DAYS PRIOR TO MATING AND THROUGHOUT GESTATION AND LACTATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PENTACHLOROPROPENE, 1,1,2,3,3,- 001600-37-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010041
PENTANE, N- 000109-66-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005603
PHENANTHRENE 000085-01-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005604
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP.
PHENOL 000108-95-2
NOAEL 60 MG/KG/DAY RAT
ORAL: GAVAGE FETUS DECREASED WEIGHT 6E-1 IRIS 005824
100
SUBCHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION. THE ORAL
CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A DEVELOPMENTAL STUDY WITH EXPOSURES DURING DAYS 6-15 OF GESTATION.
IRIS 010913
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (02/22/90) BY THE RfD/RfC WORK GROUP.
PHENYLENEDIAMINE, M- 000108-45-2
NOEL 6 MG/KG/DAY RAT
ORAL 90 DAYS LIVER LESIONS 6E-2 IRIS 010044
100
PHENYLENEDIAMINE, O- 000095-54-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. ALSO SEE HEAST TABLE 3: CARCINOGENICITY. 010042
PHENYLENEDIAMINE, P- 000106-50-3
NOAEL 18.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY EFFECTS 1.9E-1 010043
100
PHENYLMERCURIC ACETATE 000062-38-4
NOAEL 0.0084 MG/KG/DAY RAT
ORAL: DIET 2 YEARS KIDNEY DAMAGE 8E-5 IRIS 010277
10O
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD]. CALCULATED BY ANALOGY TO MERCURY BY CORRECTING
FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO MERCURY BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
PHORATE 000298-02-2
NOAEL 0.033 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS CHOLINESTERASE INHIBITION 2E-4 2E-4 010403
200 200
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PHOSGENE 000075-44-5
IRIS 010045
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (10/01/90) BY THE RfD/RfC WORK GROUP.
PHOSPHINE 007803-51-2
NOEL 0.026 MG/KG/DAY RAT
ORAL: DIET 2 YEARS 3E-4 IRIS 010174
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
NOAEL 1.4 MG/CU M MOUSE
INHALATION: 13 WEEKS WHOLE BODY DECREASED WEIGHT 3E-3 IRIS 010976
INTERMITTENT 100
PHOSPHORUS, WHITE 007723-14-0
IRIS 010452
GENERAL COMMENT: FORMERLY LISTED AS PHOSPHORUS (INORGANIC COMPOUNDS).
PHOTOCHEMICAL OXIDANTS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 010172
PHTHALIC ACID, M- 000121-91-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010047
PHTHALIC ACID, O- 000088-99-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010046
PHTHALIC ACID, P- 000100-21-0
NOEL 142 MG/KG/DAY RAT
ORAL: DIET 2 YEARS BLADDER HYPERPLASIA 1E+0 1E+0 010048
100 100
PHTHALIC ANHYDRIDE 000085-44-9
LOAEL 1562 MG/KG/DAY MOUSE
ORAL: DIET 104 WEEKS LUNG HISTOPATHOLOGY 2E+0 IRIS 010049
KIDNEY HISTOPATHOLOGY 1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
LOAEL 0.1 MG/CU M HUMAN
INHALATION: 12 YEARS NOSE RHINITIS 1.2E-1 1.2E-1 010847
INTERMITTENT LUNGS BRONCHITIS 300 300
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
POLYBROMINATED BIPHENYLS
LOAEL 0.07 MG/KG/DAY RAT
ORAL: GAVAGE 25 WEEKS LIVER INCREASED WEIGHT 7E-5 7E-6 010050
LIVER LESIONS 1000 10000
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
POTASSIUM CYANIDE 000151-50-8
NOAEL 27 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 5E-2 IRIS 010278
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
POTASSIUM SILVER CYANIDE 000506-61-6
NOAEL 82.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 2E-1 IRIS 010279
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
PROFLURALIN 026399-36-0
NOEL 3 MG/KG/DAY RAT
ORAL: DIET SUBCHRONIC NONE OBSERVED 6E-3 6E-3 010051
500 500
PRONAMIDE 023950-58-5
NOEL 7.5 MG/KG/DAY DOG
ORAL: DIET 2 YEARS NONE OBSERVED 7.5E-2 IRIS 010280
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PROPACHLOR 001918-16-7
NOEL 13.3 MG/KG/DAY RAT
ORAL: DIET 90 DAYS WHOLE BODY DECREASED WEIGHT GAIN 1.3E-1 IRIS 010175
100
PROPAZINE 000139-40-2
NOEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 2E-2 IRIS 010052
300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
PROPIONITRILE 000107-12-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010053
PROPYL ALCOHOL, N- 000071-23-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005627
PROPYLENE GLYCOL 000057-55-6
NOEL 50000 PPM DOG
ORAL: DIET 2 YEARS ERYTHROCYTES DECREASED COUNT 2E+1 005631
BLOOD DECREASED HEMATOCRIT 100
BLOOD DECREASED HEMOGLOBIN
NOEL 6 % RAT
ORAL: DIET 20 WEEKS KIDNEY LESIONS 3E+1 005629
100
IRIS 010914
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
PROPYLENE GLYCOL MONOETHYL ETHER 001569-02-4
NOEL 680 MG/KG/DAY RAT
ORAL: DRINKING 30 DAYS WHOLE BODY DECREASED WEIGHT GAIN 7E+0 7E-1 005488
WATER 100 1000
IRIS 010915
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/25/91) BY THE RfD/RfC WORK GROUP.
PROPYLENE GLYCOL MONOMETHYL ETHER 000107-98-2
NOEL 947 MG/KG/DAY RAT
ORAL: GAVAGE 35 DAYS LIVER HISTOPATHOLOGY 7E+0 7E-1 005486
KIDNEY HISTOPATHOLOGY 100 1000
NOAEL 1000 PPM RAT, RABBIT
INHALATION: 13 WEEKS CENTRAL NERVOUS EFFECTS 2E+1 IRIS 010276
INTERMITTENT SYSTEM 30
PROPYLENE OXIDE 000075-56-9
LOAEL 71 MG/CU M RAT
INHALATION: 2 YEARS EPITHELIUM UNSPECIFIED 3E-2 IRIS 010375
INTERMITTENT 100
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RFC].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
PYRENE 000129-00-0
NOAEL 75 MG/KG/DAY MOUSE
ORAL: GAVAGE 13 WKS KIDNEY EFFECTS 3E-1 IRIS 010176
300
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (08/04/94) BY THE RfD/RfC WORK GROUP. 010968
PYRIDINE 000110-86-1
NOAEL 1 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER INCREASED WEIGHT 1E-2 IRIS 010055
LIVER INCREASED RELATIVE WEIGHT 100
RDX / (CYCLONITE) 000121-82-4
NOEL 0.3 MG/KG/DAY RAT
ORAL 105 WEEKS PROSTATE INFLAMMATION 3E-3 IRIS 010056
PROSTATE HEMOSIDEROSIS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
RONNEL 000299-84-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 2 YEARS LIVER EFFECTS 5E-2 5E-2 010057
100 100
SELENIOUS ACID 007783-00-8
NOAEL 0.046 MG/KG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOSIS, CLINICAL 5E-3 IRIS 010504
3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
SELENIUM 007782-49-2
NOAEL 0.853 MG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOSIS, CLINICAL 5E-3 IRIS 010404
3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
SELENOUREA 000630-10-4
NOAEL 0.072 MG/KG/DAY HUMAN
ORAL: DIET WHOLE BODY SELENOSIS 5E-3 5E-3 010473
15 15
CHRONIC [RfD] COMMENT: WITHDRAWN FROM IRIS (05/01/91). UNDER REVIEW, CURRENT NUMBER SUBJECT TO CHANGE.
SILVER 007440-22-4
LOAEL 0.014 MG/KG/DAY HUMAN
IV 2-9 YEARS SKIN ARGYRIA 5E-3 IRIS 010453
3
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: BASED ON A TOTAL IV DOSE OF 1 GRAM.
SILVER CYANIDE 000506-64-9
NOAEL 55.7 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 1E-1 IRIS 010283
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
SIMAZINE 000122-34-9
NOAEL 0.52 MG/(KG-DAY) RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT GAIN 5E-3 IRIS 010955
BLOOD HEMATOLOGICAL EFFECTS 100
SUBCHRONIC [RfD] COMMENT: THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY
SODIUM CYANIDE 000143-33-9
NOAEL 20.4 MG/KG/DAY RAT
ORAL: DIET CENTRAL NERVOUS EFFECTS 4E-2 IRIS 005640
SYSTEM 500
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
THE ORAL CHRONIC RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
SODIUM DIETHYLDITHIOCARBAMATE 000148-18-5
NOEL 30 MG/KG/DAY RAT
ORAL 90 DAYS EYE CATARACTS 3E-1 IRIS 005644
WHOLE BODY DECREASED WEIGHT 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SODIUM METAVANADATE 013718-26-8
NOAEL 10 PPM RAT
ORAL: DRINKING 3 MONTHS KIDNEY IMPAIRED FUNCTION 1E-2 1E-3 005735
WATER 100 1000
STRONTIUM, STABLE 007440-24-6
NOAEL 190 MG/KG/DAY RAT, YOUNG
ORAL: DRINKING 20 DAYS BONE RACHITIC CHANGES 6E-1 IRIS 010842
WATER 300
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
STRYCHNINE 000057-24-9
LOAEL 2.5 MG/KG/DAY RAT
ORAL: GAVAGE 28 DAYS UNSPECIFIED TOXICITY 3E-3 IRIS 010285
UNSPECIFIED HISTOPATHOLOGY 1000
GENERAL COMMENT: THE LOAEL IS ALSO THE FEL.
STYRENE 000100-42-5
IRIS 010059
NOAEL 22 PPM HUMAN
INHALATION: CENTRAL EFFECTS 3E+0 IRIS 010511
OCCUPATIONAL NERVOUS SYSTEM 10
CHRONIC [RfC] COMMENT: THE MEAN DURATION OF EXPOSURE FOR 50 WORKERS WAS 8.6 YEARS. AIR EXPOSURE CONCENTRATIONS WERE
ESTIMATED FROM THE SUMMATION OF THE PRINCIPLE URINARY METABOLITES OF STYRENE, MANDELIC ACID AND
PHENYLGLYOXYLIC ACID. SEE IRIS FOR MORE INFORMATION.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
SUCCINONITRILE 000110-61-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005585
SULFUR DIOXIDE 007446-09-5
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010505
SULFUR OXIDES
CHRONIC [RfC] COMMENT: REFER TO APPENDIX A: TECHNICAL INFORMATION, SECTION V ON NATIONAL AMBIENT AIR QUALITY STANDARDS. 010035
SULFURIC ACID 007664-93-9
NOAEL 0.066-0.098 MG/CU M HUMAN
INHALATION RESPIRATORY RESPIRATORY EFFECTS 005647
SYSTEM
CHRONIC [RfC] COMMENT: REPORTED EFFECTS OCCURRED AT PORTAL OF ENTRY. ESTIMATES OF MG/DAY REFERENCE DOSES ARE
INAPPROPRIATE BECAUSE EFFECTS AT PORTAL OF ENTRY DEPEND ON CONCENTRATION IN AIR. AN ACCEPTABLE
AIR CONCENTRATION OF 0.07 MG/CU M WAS ESTIMATED BY CARSON ET AL (1981) FROM AVAILABLE DATA.
TEMEPHOS 003383-96-8
NOAEL 200 PPM RAT
ORAL: DIET 99 DAYS 2E-1 2E-2 010060
100 1000
TERBUFOS 013071-79-9
NOAEL 0.0025 MG/KG/DAY DOG
ORAL: DIET 6 MONTHS CHOLINESTERASE INHIBITION 2.5E-5 2.5E-5 010408
100 100
TEREPHTHALIC ACID 000100-21-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT. 010474
TETRACHLOROAZOXYBENZENE 021232-47-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010064
TETRACHLOROBENZENE, 1,2,4,5- 000095-94-3
NOAEL 0.34 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS KIDNEY LESIONS 3E-3 IRIS 010286
100
TETRACHLOROCYCLOPENTADIENE 000695-77-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005303
TETRACHLOROETHANE, 1,1,1,2- 000630-20-6
LOAEL 89.3 MG/KG/DAY RAT
ORAL: GAVAGE 103 WEEKS LIVER LESIONS 3E-2 IRIS 010407
KIDNEY LESIONS 3000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRACHLOROETHYLENE 000127-18-4
NOAEL 14 MG/KG/DAY MOUSE
ORAL 6 WEEKS LIVER HEPATOTOXICITY 1E-1 IRIS 005650
100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRACHLOROHYDRAZOBENZENE 071753-42-9
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010065
TETRACHLOROPHENOL, 2,3,4,5- 004901-51-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005324
TETRACHLOROPHENOL, 2,3,4,6- 000058-90-2
NOAEL 25 MG/KG/DAY RAT
ORAL: GAVAGE 90 DAYS LIVER INCREASED WEIGHT 3E-1 IRIS 005323
LIVER CENTRILOBULAR HYPERTROPHY 100
TETRACHLOROPHENOL, 2,3,5,6- 000935-95-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005325
TETRACHLOROPROPENE, 1,1,2,3- 010436-39-2
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010066
TETRACHLOROVINPHOS / (STIROPHOS) 000961-11-5
NOEL 3.1 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER INCREASED WEIGHT 3E-2 IRIS 010067
KIDNEY INCREASED WEIGHT 100
WHOLE BODY
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TETRAETHYL DITHIOPYROPHOSPHATE 003689-24-5
NOEL 0.5 MG/KG/DAY RAT
ORAL: DIET 3 MONTHS ERYTHROCYTES DECREASED CHOLINESTERASE 5E-3 IRIS 010287
ACTIVITY 100
BLOOD DECREASED CHOLINESTERASE
ACTIVITY
THALLIC OXIDE 001314-32-5
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL [RfD] IS CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP. 010956
THALLIUM (I) ACETATE 000563-68-8
NOAEL 0.26 MG/KG/DAY RAT
ORAL 90 DAYS LIVER INCREASED SGOT 9E-4 IRIS 005664
BLOOD INCREASED SERUM LDH 300
HAIR ALOPECIA
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CARBONATE 006533-73-9
NOAEL 0.23 MG/KG/DAY RAT
ORAL 90 DAYS LIVER INCREASED SGOT 8E-4 IRIS 005668
BLOOD INCREASED SERUM LDH 300
HAIR ALOPECIA
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM (I) CHLORIDE 007791-12-0
NOAEL 0.23 MG/KG/DAY RAT
ORAL 90 DAYS LIVER INCREASED SGOT 8E-4 IRIS 005672
BLOOD INCREASED SERUM LDH 300
HAIR ALOPECIA
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM, INSOLUBLE SALTS
CHRONIC [RfD] COMMENT: REFER TO IRIS FOR OTHER THALLIUM SALTS. 010458
THALLIUM (I) NITRATE 010102-45-1
NOAEL 0.26 MG/KG/DAY RAT
ORAL 90 DAYS LIVER INCREASED SGOT 9E-4 IRIS 005676
BLOOD INCREASED SERUM LDH 300
HAIR ALOPECIA
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO THALLIUM (I) SULFATE BY CORRECTING FOR MOLECULAR WEIGHT DIFFERENCES.
THALLIUM SELENITE 012039-52-0
010957
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS WITHDRAWN FROM IRIS (08/01/93). THE CHRONIC ORAL [RfD] IS
CONSIDERED NOT VERIFIABLE (07/22/93) BY THE RfD/RfC WORK GROUP.
THALLIUM (I) SULFATE 007446-18-6
NOAEL 0.25 MG/KG/DAY RAT
ORAL 90 DAYS LIVER INCREASED SGOT 8E-4 IRIS 005682
BLOOD INCREASED SERUM LDH 300
HAIR ALOPECIA
THIOCYANOMETHYLTHIO)BENZOTHIAZOLE, 2-( 021564-17-0
NOEL 25 MG/KG/DAY RAT
ORAL: DIET SUBCHRONIC STOMACH LESIONS 3E-1 3E-2 010068
100 1000
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
CHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA
THIOFANOX 013196-18-4
NOAEL 0.025 MG/KG/DAY DOG
ORAL 8 DAYS CHOLINESTERASE DECREASED CHOLINESTERASE 3E-4 3E-4 010069
ACTIVITY 100 100
SUBCHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
CHRONIC [RfD] COMMENT: BASED ON CONFIDENTIAL BUSINESS INFORMATION DATA.
THIRAM 000137-26-8
IRIS 010459
NOAEL 0.61 MG/KG/DAY FERRET
ORAL 24 WEEKS REPRODUCTION IMPAIRED 6E-3 010070
100
TIN AND COMPOUNDS
NOAEL 2000 PPM RAT
ORAL: DIET 2 YEARS LIVER LESIONS 6E-1 6E-1 005688
KIDNEY LESIONS 100 100
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO STANNOUS CHLORIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
TOLUENE 000108-88-3
NOAEL 223 MG/KG/DAY RAT
ORAL: GAVAGE 13 WEEKS LIVER ALTERED WEIGHT 2E+0 IRIS 010469
KIDNEY ALTERED WEIGHT 100
IRIS 010844
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
TOLUENE-2,5-DIAMINE 000095-70-5
NOAEL 56 MG/KG/DAY RAT
ORAL: DIET 78 WEEKS 6E-1 6E-1 010073
100 100
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE SULFATE SALT.
TOLUENE-2,6-DIAMINE 000823-40-5
NOAEL 16 MG/KG/DAY RAT
ORAL: DIET 2 YEARS 2E-1 2E-1 010074
100 100
SUBCHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
CHRONIC [RfD] COMMENT: DETERMINED FROM DATA OBTAINED WITH THE DIHYDROCHLORIDE.
TOLUENEDIAMINE, 2,3- 002687-25-4
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010071
TOLUENEDIAMINE, 3,4- 000496-72-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010072
TOLUIDINE, M- 000108-44-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010075
TRIALLATE 002303-17-5
NOAEL 1.275 MG/KG/DAY DOG
ORAL: DIET 24 MONTHS SPLEEN EFFECTS 1.3E-2 IRIS 010076
LIVER EFFECTS 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
TRIBROMOBENZENE, 1,2,4- 000615-54-3
NOAEL 5 MG/KG/DAY RAT
ORAL: DIET 45 OR 90 LIVER ALTERED WEIGHT 5E-2 IRIS 010077
DAYS LIVER ENZYME INDUCTION 100
TRICHLORO-1,2,2-TRIFLUOROETHANE, 1,1,2- 000076-13-1
IRIS 010460
NOEL 2000 PPM RAT
INHALATION: 24 MONTHS WHOLE BODY DECREASED WEIGHT 3E+1 3E+0 3E+1 010376
INTERMITTENT 100 100 100
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.2.
TRICHLORO-2'-HYDROXYDIPHENYLETHER, 2,2,4'- 003380-34-5
NOEL 500 MG/KG/DAY RAT
ORAL 4 WEEKS WHOLE BODY DECREASED WEIGHT 4E+0 005492
100
TRICHLOROBENZENE, 1,2,4- 000120-82-1
NOAEL 100 PPM RAT
ORAL: DRINKING ADRENAL INCREASED WEIGHT 1E-2 IRIS 010506
WATER 1000
SUBCHRONIC [RfD] COMMENT: BASED ON A MULTIGENERATION REPRODUCTION STUDY.
NOAEL 104 PPM RAT, RABBIT,
DOG, MONKEY
INHALATION 6 AND 26 LIVER NON-ADVERSE WEIGHT CHANGES 2E+0 2E-1 010958
WEEKS 100 1000
TRICHLOROCYCLOPENTADIENE 077323-84-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005304
TRICHLOROETHANE, 1,1,1- 000071-55-6
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
TRICHLOROETHANE, 1,1,2- 000079-00-5
NOAEL 3.9 MG/KG/DAY MOUSE
ORAL: DRINKING 90 DAYS BLOOD CLINICAL CHEMISTRY ALTERATIONS 4E-2 IRIS 005702
WATER 100
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRICHLOROFLUOROMETHANE 000075-69-4
IRIS 005502
LOAEL 1000 MG/KG/DAY RAT
ORAL 6 WEEKS WHOLE BODY INCREASED MORTALITY 7E-1 005500
1000
SUBCHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
CHRONIC [RfC] COMMENT: ALSO SEE HEAST TABLE 2: ALTERNATE METHODS - SUBCHRONIC AND CHRONIC TOXICITY (OTHER THAN CARCINOGENICITY)
TRICHLOROPHENOL, 2,3,4- 015950-66-0
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005330
TRICHLOROPHENOL, 2,3,5- 000933-78-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005331
TRICHLOROPHENOL, 2,3,6- 000933-75-5
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005332
TRICHLOROPHENOL, 2,4,5- 000095-95-4
NOEL 1000 PPM RAT
ORAL: DIET 98 DAYS LIVER HEPATOTOXICITY 1E+0 IRIS 005329
KIDNEY EFFECTS 100
IRIS 010919
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfD/RfC WORK GROUP.
TRICHLOROPHENOL, 2,4,6- 000088-06-2
IRIS 010461
CHRONIC RfC COMMENT: THE CHRONIC INHALATION RfC IS CONSIDERED NOT VERIFIABLE (04/24/91) BY THE RfD/RfC WORK GROUP.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRICHLOROPHENOL, 3,4,5- 000609-19-8
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005333
TRICHLOROPHENOXY) PROPIONIC ACID, 2(2,4,5- 000093-72-1
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 2 YEARS LIVER HISTOPATHOLOGY 8E-3 IRIS 010284
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
TRICHLOROPHENOXYACETIC ACID, 2,4,5- 000093-76-5
IRIS 010178
NOEL 10 MG/KG/DAY RAT
ORAL: DIET 90 DAYS KIDNEY WEIGHT EFFECTS 1E-1 010179
LIVER WEIGHT EFFECTS 100
TRICHLOROPROPANE, 1,1,1- 007789-89-1
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005705
TRICHLOROPROPANE, 1,1,2- 000598-77-6
NOEL 100 MG/L RAT
ORAL: DRINKING 13 WEEKS LIVER HISTOPATHOLOGY 5E-2 IRIS 005708
WATER KIDNEY HISTOPATHOLOGY 300
THYROID HISTOPATHOLOGY
TRICHLOROPROPANE, 1,2,2- 003175-23-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005706
TRICHLOROPROPANE, 1,2,3- 000096-18-4
NOAEL 8 MG/KG/DAY RAT
ORAL 120 DAYS WHOLE BODY TOXICITY 6E-2 IRIS 005714
LIVER LESIONS 100
KIDNEY LESIONS
ERYTHROCYTES DECREASED COUNT
BLOOD DECREASED HEMATOCRIT
BLOOD DECREASED HEMOGLOBIN
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRICHLOROPROPENE, 1,2,3- 000096-19-5
NOEL 18 MG/CU M DOG
INHALATION: 66 WEEKS EYE IRRITATION 5E-3 5E-3 010078
INTERMITTENT 100 100
SUBCHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
CHRONIC [RfD] COMMENT: BASED ON ROUTE TO ROUTE EXTRAPOLATION USING AN ABSORPTION FACTOR OF 0.5.
TRICHLOROTOLUENE, 2,3,6- 002077-46-5
LOAEL 0.5 PPM RAT
ORAL: DIET 28 DAYS LIVER LESIONS 5E-5 005335
KIDNEY LESIONS 1000
THYROID LESIONS
TRICHLOROTOLUENE, ALPHA,2,6- 002014-83-7
LOAEL 0.5 PPM RAT
ORAL: DIET 28 DAYS LIVER LESIONS 5E-5 005339
KIDNEY LESIONS 1000
THYROID LESIONS
TRIFLURALIN 001582-09-8
NOEL 0.75 MG/KG/DAY DOG
ORAL: DIET 12 MONTHS LIVER INCREASED WEIGHT 7.5E-3 IRIS 010080
BLOOD METHEMOGLOBINEMIA 100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
TRIMETHYLBENZENES
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 005727
TRINITROBENZENE, 1,3,5- 000099-35-4
NOAEL 0.51 MG/KG/DAY RAT
ORAL: WATER 16 WEEKS SPLEEN INCREASED WEIGHT 5E-4 IRIS 010081
1000
SUBCHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1,3-DINITROBENZENE.
CHRONIC [RfD] COMMENT: CALCULATED FROM DATA OBTAINED WITH 1,3-DINITROBENZENE.
TRINITROPHENOLS
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010082
TRINITROPHENYLMETHYLNITRAMINE 000479-45-8
LOAEL 125 MG/KG/DAY RABBIT
ORAL: GAVAGE 9 MONTHS LIVER HISTOPATHOLOGICAL EFFECTS 1E-1 1E-2 010377
KIDNEY HISTOPATHOLOGICAL EFFECTS 1000 10000
SPLEEN HISTOPATHOLOGICAL EFFECTS
TRINITROTOLUENE, 2,4,6- 000118-96-7
LOAEL 0.5 MG/KG/DAY DOG
ORAL: GAVAGE LIVER EFFECTS 5E-4 IRIS 010416
1000
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
VANADIUM 007440-62-2
NOAEL 5 PPM RAT
ORAL: DRINKING LIFETIME 7E-3 7E-3 005739
WATER 100 100
VANADIUM PENTOXIDE 001314-62-1
NOAEL 17.85 PPM RAT
ORAL: DIET LIFETIME 9E-3 IRIS 005743
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
VANADIUM SULFATE 036907-42-3
NOAEL 2.24 MG/KG/DAY RAT
ORAL: DRINKING LIFETIME 2E-2 2E-2 005747
WATER 100 100
VERNAM / (VERNOLATE) 001929-77-7
NOEL 1 MG/KG/DAY RAT
ORAL: DIET WHOLE BODY DECREASED WEIGHT 1E-2 IRIS 010083
100
VINYL ACETATE 000108-05-4
NOAEL 100 MG/KG/DAY RAT
ORAL: WATER 2 YEARS WHOLE BODY ALTERED WEIGHT 1E+0 1E+0 010417
KIDNEY ALTERED WEIGHT 100 100
NOAEL 176 MG/CU M MOUSE
INHALATION: 104 WEEKS NASAL CAVITY LESIONS 2E-1 IRIS 010418
INTERMITTENT 30
SUBCHRONIC [RfC] COMMENT: THE CHRONIC INHALATION RfC WAS ADOPTED AS THE SUBCHRONIC INHALATION [RfC].
VINYL CHLORIDE 000075-01-4
SUBCHRONIC [RfC] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
GENERAL COMMENT: ALSO SEE HEAST TABLE 3: CARCINOGENICITY.
VINYL-1-CYCLOHEXENE, 4- 000100-40-3
GENERAL COMMENT: DATA INADEQUATE FOR QUANTITATIVE RISK ASSESSMENT 010084
WARFARIN 000081-81-2
LOAEL 2 MG/DAY HUMAN
ORAL BLOOD INCREASED PROTHROMBIN TIME 3E-4 IRIS 010409
100
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
XYLENE, M- 000108-38-3
NOAEL 250 MG/KG RAT
ORAL: GAVAGE 103 WEEKS CENTRAL NERVOUS HYPERACTIVITY 2E+0 005755
SYSTEM 100
WHOLE BODY DECREASED WEIGHT
WHOLE BODY
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
010920
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
XYLENE, MIXTURE 001330-20-7
IRIS 010872
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
010921
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
XYLENE, O- 000095-47-6
NOEL 250 MG/KG RAT
ORAL: GAVAGE 103 WEEKS CENTRAL NERVOUS HYPERACTIVITY 2E+0 005751
SYSTEM 100
WHOLE BODY DECREASED WEIGHT
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
010922
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
XYLENE, P- 000106-42-3
SUBCHRONIC [RfD] COMMENT: CONTACT THE SUPERFUND HEALTH RISK TECHNICAL SUPPORT CENTER: (513) 569-7300.
010923
CHRONIC [RfC] COMMENT: THE CHRONIC INHALATION [RfC] IS CONSIDERED NOT VERIFIABLE (12/11/91) BY THE RfD/RfC WORK GROUP.
ZINC (METALLIC) 007440-66-6
LOAEL 1.0 MG/KG/DAY HUMAN
ORAL: DIET 10 WEEKS BLOOD DECREASED BLOOD ENZYME 3E-1 IRIS 010937
SUPPLEMENT 3
CHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
ZINC CYANIDE 000557-21-1
NOAEL 24.3 MG/KG/DAY RAT
ORAL: DIET 2 YEARS WHOLE BODY DECREASED WEIGHT 5E-2 IRIS 010289
THYROID EFFECTS 500
NERVE MYELIN DEGENERATION
SUBCHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
CHRONIC [RfD] COMMENT: CALCULATED BY ANALOGY TO FREE CYANIDE BY CORRECTING FOR DIFFERENCES IN MOLECULAR WEIGHT.
ZINC PHOSPHIDE 001314-84-7
LOAEL 3.48 MG/KG/DAY RAT
ORAL: DIET 13 WEEKS WHOLE BODY DECREASED WEIGHT 3E-3 IRIS 010290
WHOLE BODY DECREASED FOOD INTAKE 1000
ZINEB 012122-67-7
LOAEL 25 MG/KG/DAY RAT
ORAL: DIET 2 YEARS THYROID HYPERPLASIA 5E-2 IRIS 010085
500
SUBCHRONIC [RfD] COMMENT: THE CHRONIC ORAL RfD WAS ADOPTED AS THE SUBCHRONIC ORAL [RfD].
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