Health Effects Assessment Summary (HEAST) for
Zineb
CAS: 012122-67-7
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
5E-2 mg/kg/day | |||
| Uncertainty Factor: | 500 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Thyroid / Hyperplasia | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 25 mg/kg/day | 2 years | |
| References | ||||
| 1953 | Blackwell-Smith R.J. Jr., J.K. Finnegan, P.S. Larson, et al. 1953. Toxicologic studies on Zinc and Disodiumethylenebisdithiocarbamates. J Pharmacol Exp Ther. 109: 159-166. | |||
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Zineb. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC | |||
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
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