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Health Effects Assessment Summary (HEAST) for

Zinc (Metallic)

CAS: 007440-66-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 3E-1 mg/kg/day
Uncertainty Factor: 3

Route: Oral: diet supplement

Target Organ / Critical Effect: Blood / Decreased blood enzyme

Species Effect Level Dose Experiment Length
Human LOAEL 1.0 mg/kg/day 10 weeks

References
1989 Yadrick M.F., M.A. Kenney and E.A. Winterfeldt. 1989. Iron, Copper and Zinc status: Response to supplementation with Zinc or Zinc and Iron in adult females. Am J Clin Nutr. 49: 145-150.
1991 U.S. EPA. 1991. RfD/RfC Work Group.


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