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Health Effects Assessment Summary (HEAST) for
Xylene, o-
CAS: 000095-47-6
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
2E+0 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Central nervous system / Hyperactivity |
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Whole body / Decreased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
250 mg/kg |
103 weeks |
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| References |
| 1986 | NTP (National Toxicology Program). 1986. NTP technical report on the toxicology and carcinogenesis of Xylenes (mixed) (60.2% m-Xylene, 13.6% p-Xylene, 17.0% Ethylbenzene and 9.1% o-Xylene) (CAS No. 1330-20-7) in F344/N rats and B6C3F1 mice (gavage studies). US DHHS, PHS, NIH, NTP, Research Triangle Park, NC, NTP TR 327, NIH Publ No. 86-2583. |
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Xylenes (o-, m-, p-). Environmental Criteria and Assessment Office, Cincinnati, OH. Office of Solid Waste and Emergency Response, Washington, DC |
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