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Health Effects Assessment Summary (HEAST) for

Vinyl Acetate

CAS: 000108-05-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 1E+0 mg/kg/day
Uncertainty Factor: 100

Subchronic [RfD]: 1E+0 mg/kg/day
Uncertainty Factor: 100

Route: Oral: water

Target Organ / Critical Effect: Whole body / Altered weight
Kidney / Altered weight

Species Effect Level Dose Experiment Length
Rat NOAEL 100 mg/kg/day 2 years

References
1988 Shaw D.C. 1988. Vinyl acetate: 104-week oral (drinking water) combined chronic toxicity and carcinogenicity study in the rat following in vitro exposure, Volume I. Hazeleton Laboratories, UK. Report No. 5531-5/16. EPA Doc. No. 86-0000265. Fiche No. OTS0514156.
1989 U.S. EPA. 1989. Health and environmental effects document for Vinyl Acetate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington DC




Subchronic [RfC]:
(see comment)		 2E-1 mg/cu m

Uncertainty Factor: 30

Route: Inhalation: intermittent

Target Organ / Critical Effect: Nasal cavity / Lesions

Species Effect Level Dose Experiment Length
Mouse NOAEL 176 mg/cu m 104 weeks

References
1988 Owen P.E. 1988. Vinyl Acetate: 104 week inhalation combined chronic toxicity and carcinogenicity study in the rat and mouse. Report prepared by Hazelton Laboratories Europe, LTD., Harrogate, England for the Society of the Plastics Industry, Inc., New York. Report No. 5547-51/15. November, 1988.
1988 Beems R.B. 1988. Report No. V88-133: Histopathology of the respiratory tract of mice used in a 104-week inhalation study (Owen, 1988) with Vinyl Acetate. (TNO-CIVO Institutes, April, 1988).
1988 Dreef, Van der Meulen H.C. 1988. Report No. V88, 033/270836: Histopathology of the respiratory tract of rats used in a 104 week inhalation study (Owen, 1988) with Vinyl Acetate: Revised version (TNO-CIVO Institutes, October, 1988).
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfC] Comments: The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].


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