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Health Effects Assessment Summary (HEAST) for

Trinitrophenylmethylnitramine

CAS: 000479-45-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]: 1E-2 mg/kg/day
Uncertainty Factor: 10000

Subchronic [RfD]: 1E-1 mg/kg/day
Uncertainty Factor: 1000

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Histopathological effects
Kidney / Histopathological effects
Spleen / Histopathological effects

Species Effect Level Dose Experiment Length
Rabbit LOAEL 125 mg/kg/day 9 months

References
1965 Fati S., E. Daniele. 1965. Histopathological changes in experimental chronic Tetryl poisoning. Folia Med. 48(4): 260-276.
1990 U.S. EPA. 1990. Health and environmental effects document for Trinitrophenylmethylnitramine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC


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