Health Effects Assessment Summary (HEAST) for
Trinitrobenzene, 1,3,5-
CAS: 000099-35-4
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Subchronic [RfD]: (see comment) |
5E-4 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: water | |||
| Target Organ / Critical Effect: | Spleen / Increased weight | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 0.51 mg/kg/day | 16 weeks | |
| References | ||||
| 1981 | Cody T.E., S. Witherup, L. Hastings, K. Stemmer and R.T. Chustion. 1981. 1,3-Dinitrobenzene: Toxic effects in vitro. J Toxicol Environ Health. 7: 829-847. | |||
| 1989 | U.S. EPA. 1989. Health and environmental effects document for 1,3,5-Trinitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| 1988 | U.S. EPA. 1988. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Calculated from data obtained with 1,3-dinitrobenzene. | |||
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