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Health Effects Assessment Summary (HEAST) for

Trifluralin

CAS: 001582-09-8

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 7.5E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Liver / Increased weight
Blood / Methemoglobinemia

Species Effect Level Dose Experiment Length
Dog NOEL 0.75 mg/kg/day 12 months

References
1984 Hoechst Aktiengesellschaft. 1984. Confidential business information, unpublished study. MRID No. 00151908. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1984 U.S. EPA. 1984. Health and environmental effects profile for Trifluralin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
1989 U.S. EPA. 1989. RfD/RfC Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Trifluralin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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