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Health Effects Assessment Summary (HEAST) for

Trichloropropene, 1,2,3-

CAS: 000096-19-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)		 5E-3 mg/kg/day

Uncertainty Factor: 100

Subchronic [RfD]:
(see comment)		 5E-3 mg/kg/day

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Eye / Irritation

Species Effect Level Dose Experiment Length
Dog NOEL 18 mg/cu m 66 weeks

References
1978 McKenna M.J., J.F. Quast and G.A. Stevens. 1978. Results of a 90-day inhalation toxicity study of 1,2,3-Trichloropropene in laboratory animals. Toxicol Appl Pharmacol. 45: 249.
1983 U.S. EPA. 1983. Health and environmental effects profile for Chloropropenes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
Subchronic [RfD] Comments: Based on route to route extrapolation using an absorption factor of 0.5.
Chronic [RfD] Comments: Based on route to route extrapolation using an absorption factor of 0.5.


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