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Health Effects Assessment Summary (HEAST) for
Trichloropropane, 1,2,3-
CAS: 000096-18-4
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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| Carcinogenicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
6E-2 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral |
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| Target Organ / Critical Effect: |
Whole body / Toxicity |
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Liver / Lesions |
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Kidney / Lesions |
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Erythrocytes / Decreased count |
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Blood / Decreased hematocrit |
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Blood / Decreased hemoglobin |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
8 mg/kg/day |
120 days |
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| References |
| 1983 | NTP (National Toxicology Program). 1983. Final report 120-day toxicity gavage study of 1,2,3-Trichloropropane in Fischer 344 rats. Performed by Hazelton Laboratories. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Trichloropropanes. Environmental Criteria and Assessment Office, Cincinnati, OH. Office of Solid Waste and Emergency Response, Washington, DC |
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. |
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Carcinogenicity |
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| Oral [Slope Factor]: |
7E+0 (mg/kg/day)-1 |
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| Oral [Unit Risk]: |
2E-4 (µg/L)-1 |
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| Route: |
Oral: gavage |
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| Target Organ / Cancer: |
Multiple sites / Tumors, benign/malignant, combined |
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| Species |
EPA Group |
|
| Rat |
B2 |
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| References |
| 1991 | NTP (National Toxicology Program). 1991. NTP technical report on the toxicology and carcinogenesis studies of 1,2,3-Trichloropropane (CAS No. 96-18-4) in F344/N rats and B6C3F1 mice (gavage studies). Board draft NTP TR 384. NIH PUB No. 91-2839. U.S. Dept of Health and Human Services, Public Health Service, NIH, Research Triangle Park, NC. |
| 1993 | U.S. EPA. 1993. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. |
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| EPA Group Comment: |
Under review, current classification subject to change. |
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