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Health Effects Assessment Summary (HEAST) for

Trichlorophenol, 2,4,6-

CAS: 000088-06-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:IRIS
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1E-2 (mg/kg/day)-1


Route: Oral: diet

Target Organ / Cancer: Blood / Leukemia

Species Experiment Length EPA Group
Mouse 107 weeks IRIS

References
1979 NCI (National Cancer Institute). 1979. Bioassay of 2,4,6-Trichlorophenol for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 155, DHEW No. NIH 79-1711.
1980 U.S. EPA. 1980. Ambient Water Quality Criteria document for Chlorinated Phenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Washington, DC.
1984 U.S. EPA. 1984. Health effects assessment for 2,4,6-Trichlorophenol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1987 U.S. EPA. 1987. Health and environmental effects document for Chlorinated Phenols. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1989 U.S. EPA. 1989. Carcinogen Risk Assessment Verification (CRAVE) Work Group.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.


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