HEAST Summary

Health Effects Assessment Summary (HEAST) for
Trichlorofluoromethane

CAS: 000075-69-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Alternative Methods

Chronic [RfC]: on-Line

Subchronic [RfC]: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:	7E-1 mg/kg/day
Uncertainty Factor:	1000

Route:	Oral

Target Organ / Critical Effect:	Whole body / Increased mortality

Species	Effect Level	Dose	Experiment Length
Rat	LOAEL	1000 mg/kg/day	6 weeks

References
1978	NCI (National Cancer Institute). 1978. Bioassay of Trichlorofluoromethane for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 106. Also publ as DHEW (NIH) 78-1356
1987	U.S. EPA. 1987. Health effects assessment for fully Halogenated Methanes. Environmental Criteria and Assessment Office, Cincinnati, OH. Office of Emergency and Remedial Response, Washington, DC


Alternate Methods -- Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfC]: (see comment)	7E-1 mg/cu m

Uncertainty Factor:	10000

Subchronic [RfC]: (see comment)	7E+0 mg/cu m

Uncertainty Factor:	1000

Route:	Inhalation: continuous

Target Organ / Critical Effect:	Kidney / Increased bun
	Lung / Inflammation

Species	Effect Level	Dose	Experiment Length
Dog	LOAEL	1940 mg/kg/day	90 days

References
1970	Jenkins, L.J., R.A. Jones, R.A. Coon and J. Siegal. 1970. Repeated and continuous exposures of laboratory animals to Trichlorofluormethane. Toxicol Appl Pharmacol. 16: 133-142.
1987	U.S. EPA. 1987. Health effects assessment for fully halogenated Methanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.

Subchronic [RfC] Comments:	2E+0 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
Chronic [RfC] Comments:	2E-1 mg/kg/day (see Appendix A-II, Dose Conversions on HEAST).
General Comments:	The subchronic and chronic inhalation [RfC] values were derived from methodology that is not current with the interim inhalation methodology used by the RfD/RfC work group.

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