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Health Effects Assessment Summary (HEAST) for

Trichloroethane, 1,1,2-

CAS: 000079-00-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 4E-2 mg/kg/day
Uncertainty Factor: 100

Route: Oral: drinking water

Target Organ / Critical Effect: Blood / Clinical chemistry alterations

Species Effect Level Dose Experiment Length
Mouse NOAEL 3.9 mg/kg/day 90 days

References
1985 White K.L. Jr., V.M. Sanders, V.W. Barnes, G.M. Shopp and A.E. Munson. 1985. Toxicology of 1,1,2 Trichloroethane in the mouse. Drug Chem Toxicol. 8(5): 333-355.
1985 Sanders V.M., K.L. White Jr., G.M. Shopp Jr. and A.E. Munson. 1985. Humoral and cell mediated immune status of mice exposed to 1,1,2-Trichloroethane. Drug Chem Toxicol. 8(5): 357-372.
1990 U.S. EPA. 1990. RfD/RfC Work Group.





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		5.7E-2 (mg/kg/day)-1


Route: Oral: gavage

Target Organ / Cancer: Liver / Carcinoma

Species Experiment Length EPA Group
Mouse 78 weeks IRIS

References
1978 NCI (National Cancer Institute). 1978. Bioassay of 1,1,2-Trichloroethane for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 74, DHEW No. NIH 78-1324.
1980 U.S. EPA. 1980. Ambient Water Quality Criteria document for Chlorinated Ethanes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water Regulations and Standards, Washington, DC.
1984 U.S. EPA. 1984. Health effects assessment for 1,1,2-Trichloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1986 U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.


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