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Health Effects Assessment Summary (HEAST) for

Trichlorobenzene, 1,2,4-

CAS: 000120-82-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1E-2 mg/kg/day

Uncertainty Factor: 1000

Route: Oral: drinking water

Target Organ / Critical Effect: Adrenal / Increased weight

Species Effect Level Dose
Rat NOAEL 100 ppm

References
1981 Robinson K.S., R.J. Kavlock, N. Chernoff and E. Gray. 1981. Multigeneration study of Trichlorobenzene in rats. J Toxicol Environ Health. 8: 489-500.
1991 U.S. EPA. 1991. Drinking water criteria document for 1,2,4-Trichlorobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC
Subchronic [RfD] Comments: Based on a multigeneration reproduction study.




Chronic [RfC]: 2E-1 mg/cu m
Uncertainty Factor: 1000

Subchronic [RfC]: 2E+0 mg/cu m
Uncertainty Factor: 100

Route: Inhalation

Target Organ / Critical Effect: Liver / Non-adverse weight changes

Species Effect Level Dose Experiment Length
Rat, Rabbit, Dog, Monkey NOAEL 104 ppm 6 and 26 weeks

References
1981 Kociba R.J., B.K.L. Leong, R.E. Hefner, Jr. 1981. Subchronic toxicity study of 1,2,4-Trichlorobenzene in the rat, rabbit and beagle dog. Drug and Chemical Toxicology. 4(3): 229-249.
1977 Coate W.B., T.R. Lewis, W.M. Busey. 1977. Chronic inhalation exposure of rats, rabbits and monkeys to 1,2,4-Trichlorobenzene. Archives of Environmental Health. 32(6): 249-255.
1988 Cote M., I. Chu, D.C. Velleneuve, V.E. Secours, V.E. Valli. 1988. Trichlorobenzenes: Results of a thirteen-week feeding study in the rat. Drug and Chemical Toxicology. 11(1): 11-28.
1993 U.S. EPA. 1993. RfD/RfC Work Group.


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