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Health Effects Assessment Summary (HEAST) for

Trichloro-1,2,2-Trifluoroethane, 1,1,2-

CAS: 000076-13-1

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:on-Line
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E+0 mg/kg/day

Uncertainty Factor: 100

Chronic [RfC]: 3E+1 mg/cu m
Uncertainty Factor: 100

Subchronic [RfC]: 3E+1 mg/cu m
Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Whole body / Decreased weight

Species Effect Level Dose Experiment Length
Rat NOEL 2000 ppm 24 months

References
1988 Trachimowicz H.J., G.M. Rusch, T. Chiu, et al. 1988. Chronic inhalation toxicity/carcinogenicity study in rats exposed to Fluorocarbon 113 (FC-113). Fund Appl Toxicol. 11(1): 68-75.
1990 U.S. EPA. 1990. Health and environmental effects document for 1,1,2-Trichloro-1,2,2-trifluoroethane. Prepared by theOffice of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for theOffice of Solid Waste, Washington, DC
Subchronic [RfD] Comments: Based on route to route extrapolation using an absorption factorof 0.2.


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