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Health Effects Assessment Summary (HEAST) for
Tribromobenzene, 1,2,4-
CAS: 000615-54-3
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
5E-2 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Liver / Altered weight |
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Liver / Enzyme induction |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOAEL |
5 mg/kg/day |
45 or 90 days |
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| References |
| 1977 | Carlson G.P. and R.G. Tardiff. 1977. Effect of 1,4-Dibromodibenzene and 1,2,4-Tribromobenzene on xenobiotic metabolism. Toxicol Appl Pharmacol. 42: 189-196. |
| 1984 | U.S. EPA. 1984. Health and environmental effects profile for Bromobenzenes. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
| 1986 | U.S. EPA. 1986. RfD/RfC Work Group. |
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