|
|
|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
Chronic [RfD]: (see comment) |
2E-1 mg/kg/day |
|
Uncertainty Factor: |
100 |
|
Subchronic [RfD]: (see comment) |
2E-1 mg/kg/day |
|
Uncertainty Factor: |
100 |
|
Route: |
Oral: diet |
|
|
Species |
Effect Level |
Dose |
Experiment Length |
Rat |
NOAEL |
16 mg/kg/day |
2 years |
|
References |
1980 | NCI (National Cancer Institute). 1980. Bioassay of 2,6-Toluenediamine Dihydrochloride for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 200. |
1984 | U.S. EPA. 1984. Health and environmental effects profile for selected Toluenediamines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC |
|
Subchronic [RfD] Comments: |
Determined from data obtained with the dihydrochloride. |
Chronic [RfD] Comments: |
Determined from data obtained with the Dihydrochloride. |
|