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Health Effects Assessment Summary (HEAST) for

Toluene-2,6-Diamine

CAS: 000823-40-5


Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:on-Line
Subchronic [RfD]:on-Line
Notes/Comments:on-Line






Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Chronic [RfD]:
(see comment)
2E-1 mg/kg/day

Uncertainty Factor: 100

Subchronic [RfD]:
(see comment)
2E-1 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet


Species Effect Level Dose Experiment Length
Rat NOAEL 16 mg/kg/day 2 years

References
1980 NCI (National Cancer Institute). 1980. Bioassay of 2,6-Toluenediamine Dihydrochloride for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 200.
1984 U.S. EPA. 1984. Health and environmental effects profile for selected Toluenediamines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC

Subchronic [RfD] Comments: Determined from data obtained with the dihydrochloride.
Chronic [RfD] Comments: Determined from data obtained with the Dihydrochloride.



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