|
|
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
|
Subchronic [RfD]: (see comment) |
8E-4 mg/kg/day |
|
Uncertainty Factor: |
300 |
|
Route: |
Oral |
|
Target Organ / Critical Effect: |
Liver / Increased SGOT |
|
Blood / Increased serum LDH |
|
Hair / Alopecia |
|
Species |
Effect Level |
Dose |
Experiment Length |
Rat |
NOAEL |
0.23 mg/kg/day |
90 days |
|
References |
1986 | U.S. EPA. 1986. Subchronic (90 day) toxicity of Thallium (I) Sulfate (CAS No. 7446-18-6) in Sprague-Dawley rats. Final report. Environmental Criteria and Assessment Office, Cincinnati, OH Office of Solid Waste and Emergency Response, Washington, DC |
1988 | U.S. EPA. 1988. Health and environmental effects document for Thallium and compounds. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
1988 | U.S. EPA. 1988. RfD/RfC Work Group. |
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Subchronic [RfD] Comments: |
Calculated by analogy to Thallium (I) Sulfate by correcting for molecular weight differences. |
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