HEAST Summary

Health Effects Assessment Summary (HEAST) for
Tetrachlorovinphos / (Stirofos)

CAS: 000961-11-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity

Chronic [RfD]: IRIS

Subchronic [RfD]: on-Line

Notes/Comments: on-Line

Carcinogenicity

Oral [Slope Factor]: on-Line

Oral [Unit Risk]: on-Line

EPA Group: on-Line

Notes/Comments: on-Line


Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: (see comment)	3E-2 mg/kg/day

Uncertainty Factor:	100

Route:	Oral: diet

Target Organ / Critical Effect:	Liver / Increased weight
	Kidney / Increased weight

Species	Effect Level	Dose	Experiment Length
Dog	NOEL	3.1 mg/kg/day	2 years

References
1968	Shell Chemical Company. 1968. Confidential business information, unpublished study. Accession No. 115684.
1984	U.S. EPA. 1984. Health and environmental effects profile for Stirofos. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
1986	U.S. EPA. 1986. RfD/RfC Work Group.

Subchronic [RfD] Comments:	The chronic oral RfD was adopted as the subchronic oral [RfD].


Carcinogenicity

Oral [Slope Factor]:	2.4E-2 (mg/kg/day)^-1

Oral [Unit Risk]:	6.9E-7 (µg/L)^-1

Route:	Oral: diet

Target Organ / Cancer:	Liver / Tumors

Species	Experiment Length	EPA Group
Mouse	560 days	C

References
1978	NCI (National Cancer Institute). 1978. Bioassay of Tetrachlorovinphos for possible carcinogenicity. NCI Carcinogen Tech Rep Ser No. 33. NTIS PB278650.
1984	U.S. EPA. 1984. Health and environmental effects profile for Stirofos. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

EPA Group Comment:	Under review, classification subject to change.

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