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Health Effects Assessment Summary (HEAST) for
Tetrachloroethylene, 1,1,2,2-
CAS: 000127-18-4
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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|
|
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
1E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral |
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| Target Organ / Critical Effect: |
Liver / Hepatotoxicity |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Mouse |
NOAEL |
14 mg/kg/day |
6 weeks |
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| References |
| 1985 | Buben J.A. and E.J. O'Flaherty. 1985. Delineation of the role of metabolism in the hepatoxicity of Trichloroethylene and Perchloroethylene: A dose-effect study. Toxicol Appl Pharmacol. 78: 105-122. |
| 1987 | U.S. EPA. 1987. RfD/RfC Work Group. |
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