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Health Effects Assessment Summary (HEAST) for

Tetrachloroethane, 1,1,1,2-

CAS: 000630-20-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 3000

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Lesions
Kidney / Lesions

Species Effect Level Dose Experiment Length
Rat LOAEL 89.3 mg/kg/day 103 weeks

References
1983 NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2-Tetrachloroethane in F344/N rats and B6C3F1 mice. NTP, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for Tetrachloroethane, 1,1,1,2-. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		2.6E-2 (mg/kg/day)-1


Route: Oral: gavage

Target Organ / Cancer: Liver / Tumor

Experiment Length EPA Group
103 weeks IRIS

References
1983 NTP (National Toxicology Program). 1983. Carcinogenesis studies of 1,1,1,2-Tetrachloroethane (CAS No. 630-20-6) in F344/N rats and B6C3F1 mice (gavage studies). NTP-81-53. NIH Publ No. 83-1793, NTP Technical Report Series No. 237. NTIS, Springfield, VA.
1988 U.S. EPA. 1988. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
1993 U.S. EPA. 1993. Revised and updated drinking water quantification of toxicologic effects for 1,1,1,2-Tetrachloroethane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Water, Washington, DC.
Inhalation Slope Comment: Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST.


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