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Health Effects Assessment Summary (HEAST) for

TCDD, 2,3,7,8-

CAS: 001746-01-6

Summary of HEAST Information on-Line

Carcinogenicity
Oral [Slope Factor]:on-Line
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 1.5E+5 (mg/kg/day)-1


Inhalation [Slope Factor]:
(see comment)		1.5E+5 (mg/kg/day)-1


Oral [Unit Risk]: 4.5E+0 (µg/L)-1

Inhalation [Unit Risk]:
(see comment)		 3.3E-5 (pg/m3)-1


Route: Oral: diet

Target Organ / Cancer: Respiratory system / Tumors
Liver / Tumors

Species Experiment Length EPA Group
Rat 720 days B2

References
1978 Kociba, R.J., D.G. Keyes, J.E. Bower et al. 1978. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in rats. Toxicol Appl Pharmacol. 46(2): 279-303.
1985 U.S. EPA. 1985. Health assessment document for Polychlorinated Dibenzo-p-dioxin. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH. EPA 600/8-84-014f. NTIS PB86-122546.
1984 U.S. EPA. 1984. Health effects assessment for 2,3,7,8-TCDD. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC.
1989 U.S. EPA. 1989. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Oral Slope Comment: Under review, number subject to change.
Inhalation Slope Comment: See Appendix A-II: Dose Conversions on HEAST.
Inhalation [Unit Risk] Comment: Under review, number subject to change. Based on route to route extrapolation. An absorption factor of 75% is used to calculate the unit risk from the slope factor.


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