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Health Effects Assessment Summary (HEAST) for

Strontium, Stable

CAS: 007440-24-6

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 6E-1 mg/kg/day

Uncertainty Factor: 300

Route: Oral: drinking water

Target Organ / Critical Effect: Bone / Rachitic changes

Species Effect Level Dose Experiment Length
Rat, young NOAEL 190 mg/kg/day 20 days

References
1961 Storey E. 1961. Strontium 'rickets' bone calcium and Strontium changes. Austral Ann Med. 10: 2132-222.
1981 Skoryna S.C. 1981. Effects of oral supplementation with stable Strontium. Can Med Assoc J. 125: 703-712.
1985 Marie P.J., M.T. Garba, M. Hott and L. Miravet. 1985. Effect of low doses of stable Strontium on bone metabolism in rats. Miner Electrolyte Metab. 11: 5-13.
1990 U.S. EPA. 1990. Health and environmental effects document for stable Strontium. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1992 U.S. EPA. 1992. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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