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Health Effects Assessment Summary (HEAST) for
Sodium Diethyldithiocarbamate
CAS: 000148-18-5
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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| Carcinogenicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
3E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral |
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| Target Organ / Critical Effect: |
Eye / Cataracts |
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Whole body / Decreased weight |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
30 mg/kg/day |
90 days |
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| References |
| 1967 | Sunderman F.W., O.E. Paynter and R.B. George. 1967. The effects of the protracted administration of the chelating agent, Sodium Diethyldithiocarbamate (Dithiocarb). Am J Med Sci. 254: 46-56. |
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Sodium Diethyldithiocarbamate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
| 1985 | U.S. EPA. 1985. RfD/RfC Work Group. |
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Carcinogenicity |
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| Oral [Slope Factor]: |
2.7E-1 (mg/kg/day)-1 |
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| Oral [Unit Risk]: |
7.7E-6 (µg/L)-1 |
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| Route: |
Oral: diet |
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| Target Organ / Cancer: |
Liver / Tumors |
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| Species |
Experiment Length |
EPA Group |
| Mouse |
77 weeks |
C |
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| References |
| 1968 | BRL (Bionetics Research Laboratories). 1968. Evaluation of carcinogenic teratogenic and mutagenic activities of selected pesticides on industrial chemicals. Vol. I. Carcinogenic study. Prepared for National Cancer Institute. U.S. Dept Commerce, Nat Tech Info Serv, Washington, DC. NTIS PB223159. |
| 1988 | U.S. EPA. 1988. Health and environmental effects document for Sodium Diethyldithiocarbamate. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. |
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