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Health Effects Assessment Summary (HEAST) for

Simazine

CAS: 000122-34-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 5E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet

Target Organ / Critical Effect: Whole body / Decreased weight gain
Blood / Hematological effects

Species Effect Level Dose Experiment Length
Rat NOAEL 0.52 mg/(kg-day) 2 years

References
1988 Ciba-Geigy Corp. 1988. MRID No. 40614405, HED Document No. 007240, 007449. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1991 U.S. EPA. 1991. RfD/RfC Work Group.
Subchronic [RfD] Comments: The oral chronic RfD was adopted as the subchronic oral [RfD].





Carcinogenicity
Oral [Slope Factor]:
(see comment)		 1.2E-1 (mg/kg/day)-1


Oral [Unit Risk]: 3.4E-6 (µg/L)-1

Route: Oral: diet

Target Organ / Cancer: Mammary / Carcinoma

Species Experiment Length EPA Group
Rat 2 years C

References
1984 U.S. EPA. 1984. Health and environmental effects profile for Simazine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1989 U.S. EPA. 1989. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Oral Slope Comment: Under review, number subject to change.


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