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Health Effects Assessment Summary (HEAST) for

Silver Cyanide

CAS: 000506-64-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 1E-1 mg/kg/day

Uncertainty Factor: 500

Route: Oral: diet

Target Organ / Critical Effect: Whole body / Decreased weight
Thyroid / Effects
Nerve / Myelin degeneration

Species Effect Level Dose Experiment Length
Rat NOAEL 55.7 mg/kg/day 2 years

References
1955 Howard J.W. and R.F. Hanzal. 1955. Chronic toxicity for rats of food treated with Hydrogen Cyanide. Agric Food Chem. 3: 325-329.
1979 Philbrick D.J., J.B. Hopkins, D.C. Hill, J.C. Alexander and R.G. Thomson. 1979. Effects of prolonged Cyanide and Thiocyanate feeding in rats. J Toxicol Environ Health. 5: 579-592.
1984 U.S. EPA. 1984. Health effects assessment for Sodium Cyanide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH. Office of Emergency and Remedial Response, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: Calculated by analogy to free cyanide by correcting for differences in molecular weight. The oral chronic RfD was adopted as the subchronic oral [RfD].


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