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Health Effects Assessment Summary (HEAST) for

RDX / (Cyclonite)

CAS: 000121-82-4

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-3 mg/kg/day

Uncertainty Factor: 100

Route: Oral

Target Organ / Critical Effect: Prostate / Inflammation
Prostate / Hemosiderosis

Species Effect Level Dose Experiment Length
Rat NOEL 0.3 mg/kg/day 105 weeks

References
1984 Levine B.S., E.M. Furedi, V.S. Rae, D.E. Gordon and D.M. Lish. 1984. Determination of the chronic mammalian toxicological effects of RDX: Twenty-four month chronic toxicity/carcinogenicity study of Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) in the Fischer 344 rat. NTIS AD-A160774. Vol 1. 347 p.
1989 U.S. EPA. 1989. Health and environmental effects document for RDX (Cyclonite). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1988 U.S. EPA. 1988. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].


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