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Health Effects Assessment Summary (HEAST) for
Pyrene
CAS: 000129-00-0
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
3E-1 mg/kg/day |
| Uncertainty Factor: |
300 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Kidney / Effects |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Mouse |
NOAEL |
75 mg/kg/day |
13 wks |
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| References |
| 1989 | U.S. EPA. 1989. Mouse oral subchronic toxicity study of Pyrene. Study conducted by Toxicity Research Laboratories, Muskegon, MI for the Office of Solid Waste, Washington, DC |
| 1984 | U.S. EPA. 1984. Health effects assessment for Pyrene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC |
| 1991 | U.S. EPA. 1991. Drinking water criteria document for Pyrene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Drinking Water, Washington, DC |
| 1989 | U.S. EPA. 1989. RfD/RfC Work Group. |
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