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Health Effects Assessment Summary (HEAST) for

Propylene Oxide

CAS: 000075-56-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Inhalation [Slope Factor]:on-Line
Oral [Unit Risk]:IRIS
Inhalation [Unit Risk]:IRIS
EPA Group:IRIS
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]:
(see comment)		 3E-2 mg/cu m

Uncertainty Factor: 100

Route: Inhalation: intermittent

Target Organ / Critical Effect: Epithelium / Unspecified

Species Effect Level Dose Experiment Length
Rat LOAEL 71 mg/cu m 2 years

References
1988 Kuper C.F., P.G.J. Reuzel, V.J. Feron, et al. 1988. Chronic inhalation toxicity and carcinogenicity of Propylene Oxide in Wistar rats. Food Chem Toxicol. 26(2): 159-167.
1985 U.S. EPA. 1985. Health and environmental effects profile for Propylene Xxide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfC] Comments: The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		1.3E-2 (mg/kg/day)-1


Route: Inhalation: intermittent

Target Organ / Cancer: Nasal cavity / Tumors

Species Experiment Length EPA Group
Mouse 2 years IRIS

References
1985 NTP (National Toxicology Program). 1985. Toxicology and carcinogenesis studies of Propylene oxide (CAS No. 75-56-9) in F344/N rats and B6C3F1 mice (inhalation studies). NTP Tech Rep Ser No. 267. NTP, Research Triangle Park, NC. NIH Pub No. 85-2527.
1986 Renne R.A., W.E. Giddens, G.A. Boorman, R. Kovatch, J.E. Haseman and W.J. Clarke. 1986. Nasal cavity neoplasia in F344/N rats and (C57BL/6 x C3H)F1 mice inhaling Propylene oxide for up to two years. J Natl Cancer Inst. 77: 573-582.
1990 U.S. EPA. 1990. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group.
Inhalation Slope Comment: See Appendix A-II, Dose Conversions on HEAST.


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