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Health Effects Assessment Summary (HEAST) for
Propylene Glycol Monomethyl Ether
CAS: 000107-98-2
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
7E-1 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Subchronic [RfD]: |
7E+0 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Liver / Histopathology |
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Kidney / Histopathology |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
947 mg/kg/day |
35 days |
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| References |
| 1954 | Rowe V.K., D.D. McCollister, H.C. Spencer et al. 1954. Toxicology of mono-, di-, and tri-Propylene Glycol Methyl Ethers. Arch Ind Hyg Occup Med. 9: 509-525. |
| 1984 | U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC EPA 540/1-86-052. |
| 1991 | U.S. EPA. 1991. RfD/RfC Work Group. |
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| Subchronic [RfC]: |
2E+1 mg/cu m |
| Uncertainty Factor: |
30 |
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| Route: |
Inhalation: intermittent |
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| Target Organ / Critical Effect: |
Central nervous system / Effects |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat, Rabbit |
NOAEL |
1000 ppm |
13 weeks |
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| References |
| 1983 | Landry T.D., T.S. Gunshow and B.L. Yano. 1983. Propylene Glycol Monomethyl Ether: A 13-week inhalation study in rats and rabbits. Fund Appl Toxicol. 3: 627-630 |
| 1984 | Miller R.R., E.A. Herman, J.T. Young et al. 1984. Ethylene Glycol Monomethyl Ether: Metabolism, disposition, and subchronic inhalation toxicity studies. Environ Health Perspect. 57: 233-239. |
| 1984 | U.S. EPA. 1984. Health effects assessment for Glycol Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Emergency and Remedial Response, Washington, DC EPA 540/1-86-052. |
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