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Health Effects Assessment Summary (HEAST) for
Propylene Glycol
CAS: 000057-55-6
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Subchronic [RfD]: |
3E+1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Kidney / Lesions |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
6 % |
20 weeks |
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| References |
| 1947 | Guerrant N.B., G.P. Whitlock, M.L. Wolff and R.A. Dutcher. 1947. Response of rats to diets containing varying amounts of Glycerol and Propylene Glycol. Bull Natl Formulary Comm. 15: 204-229. Cited in Informatics, Inc, 1973. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Propylene Glycol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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| Chronic [RfD]: |
2E+1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Erythrocytes / Decreased count |
|
Blood / Decreased hematocrit |
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Blood / Decreased hemoglobin |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Dog |
NOEL |
50000 ppm |
2 years |
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| References |
| 1972 | Gaunt I.F., R.M.B. Carpanini, P. Grasso and A.B.G. Lansdown. 1972. Long-term toxicity of Propylene Glycol in rats. Food Cosmet Toxicol. 10: 151-162. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Propylene Glycol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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