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Health Effects Assessment Summary (HEAST) for
Polybrominated Biphenyls
CAS: CURENO-06-1
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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| Carcinogenicity |
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|
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|
|
Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
7E-6 mg/kg/day |
| Uncertainty Factor: |
10000 |
|
| Subchronic [RfD]: |
7E-5 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Liver / Increased weight |
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Liver / Lesions |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
LOAEL |
0.07 mg/kg/day |
25 weeks |
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| References |
| 1983 | NTP (National Toxicology Program). 1983. Carcinogenesis studies of Polybrominated Biphenyl mixture in F344/N rats and B6C3F1 mice (gavage studies). Firemaster FF-1. Case No. 67774-32-7. NTP, Research Triangle Park, NC. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Polybrominated Biphenyls. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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|
|
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Carcinogenicity |
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| Oral [Slope Factor]: |
8.9E+0 (mg/kg/day)-1 |
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| Oral [Unit Risk]: |
2.5E-4 (µg/L)-1 |
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| Route: |
Oral: gavage |
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| Target Organ / Cancer: |
Liver / Carcinoma |
|
Liver / Neoplastic nodule |
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| Species |
Experiment Length |
EPA Group |
| Rat |
25 weeks |
B2 |
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| References |
| 1983 | NTP (National Toxicology Program). 1983. Carcinogenesis studies of Polybrominated Biphenyl mixture in F344/N rats and B6C3F1 mice (gavage studies). Firemaster FF-1. Case No. 67774-32-7. NTP, Research Triangle Park, NC. |
| 1989 | U.S. EPA. 1989. Health and environmental effects profile for Polybrominated Biphenyls (PBBs). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. |
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