Health Effects Assessment Summary (HEAST) for
Phthalic Anhydride
CAS: 000085-44-9
| Summary of HEAST Information on-Line | ||||||||||
| Subchronic and Chronic Toxicity | ||||||||||
|
| Subchronic [RfD]: (see comment) |
2E+0 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Lung / Histopathology | |||
| Kidney / Histopathology | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Mouse | LOAEL | 1562 mg/kg/day | 104 weeks | |
| References | ||||
| 1979 | NCI (National Cancer Institute). 1979. Bioassay of Phthalic Anhydride for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 159. NTIS PB293594. | |||
| 1988 | U.S. EPA. 1988. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | The chronic oral RfD was adopted as the subchronic oral [RfD]. | |||
| Chronic [RfC]: | 1.2E-1 mg/cu m | |||
| Uncertainty Factor: | 300 | |||
| Subchronic [RfC]: (see comment) |
1.2E-1 mg/cu m | |||
| Uncertainty Factor: | 300 | |||
| Route: | Inhalation: intermittent | |||
| Target Organ / Critical Effect: | Nose / Rhinitis | |||
| Lungs / Bronchitis | ||||
| Species | Effect Level | Dose | Experiment Length | |
| Human | LOAEL | 0.1 mg/cu m | 12 years | |
| References | ||||
| 1988 | Nielsen J., H. Welinder, A. Schutz and S. Skerfving. 1988. Specific serum antibodies against Phthalic Anhydride in occupationally exposed subjects. J Allergy Clin Immunol. 82: 126-33. | |||
| 1992 | U.S. EPA. 1992. Health and enviornmental effects documentfor Phthalic Anhydride. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Subchronic [RfC] Comments: | The chronic inhalation [RfC] was adopted as the subchronic inhalation [RfC]. | |||
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