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Health Effects Assessment Summary (HEAST) for
Phthalic Acid, p-
CAS: 000100-21-0
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
1E+0 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Subchronic [RfD]: |
1E+0 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Bladder / Hyperplasia |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
NOEL |
142 mg/kg/day |
2 years |
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| References |
| 1982 | CIIT (Chemical Industry Institute of Technology). 1982. A ninety-day study of Terephthalic Acid-induced urolithiasis and reproductive performance in Wistar and CD rats. CIIT, Research Triangle Park, NC |
| 1974 | Gross J. 1974. The effects of prolonged feeding of Terephthalic Acid (TPA) to rats. Project FG-IS-175. Agricultural Research Service, US Department of Agriculture, Washington, DC |
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Phthalic Acids (o-, m-, p-). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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