EPA Home PageSuperfund Risk Assessment Home Page


Health Effects Assessment Summary (HEAST) for

Phosphine

CAS: 007803-51-2

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-4 mg/kg/day

Uncertainty Factor: 100

Route: Oral: diet


Species Effect Level Dose Experiment Length
Rat NOEL 0.026 mg/kg/day 2 years

References
1972 Hackenberg, J. 1972. Chronic ingestion by rats of standard diet treated with Aluminum Phosphide. Toxicol Appl Pharmacol. 23: 147-158.
1989 U.S. EPA. 1989. Health and environmental effects document for Phosphine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].




Subchronic [RfC]: 3E-3 mg/cu m

Route: Inhalation: intermittent

Target Organ / Critical Effect: Whole body / Decreased weight

Species Effect Level Dose Experiment Length
Mouse NOAEL 1.4 mg/cu m 13 weeks

References
1994 Barbosa A., E. Rosinova, J. Dempsey and A.M. Bonin. 1994. Determination of genotoxic and other effects in mice following short-term, repeated dose, and subchronic inhalation exposure to Phosphine. Environ. Molec. Mutagenesis 24: 81-88.
1995 U.S. EPA. 1995. RfD/RfC Work Group.


[ Risk Assessment Home ]
[ EPA Home | OSWER Home | Superfund Home ]
[ Search EPA | Search Superfund | Whats New | Contact Us ]
Horizontal Rule
URL: http://risk.lsd.ornl.gov/epa/heast/heast_select.htm
This page was last updated on: March 1, 2000
Site maintained by: Office of Emergency and Remedial Response
Hofmann.Lee@epamail.epa.gov
Horizontal Rule