Health Effects Assessment Summary (HEAST) for
Phorate
CAS: 000298-02-2
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: | 2E-4 mg/kg/day | |||
| Uncertainty Factor: | 200 | |||
| Subchronic [RfD]: (see comment) |
2E-4 mg/kg/day | |||
| Uncertainty Factor: | 200 | |||
| Route: | Oral: diet | |||
| Target Organ / Critical Effect: | Cholinesterase / Inhibition | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | NOAEL | 0.033 mg/kg/day | 13 weeks | |
| References | ||||
| 1956 | Tusing T.W. 1956. 13-week subacute Thimet feeding study in male and female rats. Unpublished report of the American Cyanamid Co. Initial scientific and mini-economic review of Phorate (Thimet). Office of Pesticide Programs, U.S. EPA, Washington, DC | |||
| 1985 | U.S. EPA. 1985. Summary of acceptable daily intakes (adis) for oral exposure. Prepared by Environmental Criteria and Assessment Office, Cincinnati, OH. Internal review draft, May, 1985. ECAO-CIN-432. | |||
| 1977 | NAS (National Academy of Sciences). 1977. Drinking Water and Health. Safe Drinking Water Committee, National Research Council. NAS, Washington, DC pp. 613-620. | |||
| Subchronic [RfD] Comments: | The chronic oral [RfD] was adopted as the subchronic oral [RfD]. | |||
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