Health Effects Assessment Summary (HEAST) for
Phenylenediamine, o-
CAS: 000095-54-5
| Summary of HEAST Information on-Line | ||||||||
| Carcinogenicity | ||||||||
|
| Oral [Slope Factor]: (see comment) |
4.7E-2 (mg/kg/day)-1 | |||
| Oral [Unit Risk]: | 1.3E-6 (µg/L)-1 | |||
| Route: | Oral: diet | |||
| Target Organ / Cancer: | Liver / Tumors | |||
| Species | Experiment Length | EPA Group | ||
| Rat | 548 days | B2 | ||
| References | ||||
| 1978 | Weisburger E.K., A.B. Russfield and F. Homburger, et al. 1978. Testing of twenty-one environmental aromatic Amines or derivatives for long-term toxicity or carcinogenicity. J Environ Pathol Toxicol. 2(2): 325-356. | |||
| 1985 | U.S. EPA. 1985. Health and environmental effects profile for o-Phenylenediamine. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| Oral Slope Comment: | Based on liver tumors in rats treated with 0-Phenylenediamine Dihydrochloride. | |||
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