Health Effects Assessment Summary (HEAST) for
Phenol
CAS: 000108-95-2
| Summary of HEAST Information on-Line | ||||||||
| Subchronic and Chronic Toxicity | ||||||||
|
| Subchronic [RfD]: (see comment) |
6E-1 mg/kg/day | |||
| Uncertainty Factor: | 100 | |||
| Route: | Oral: gavage | |||
| Target Organ / Critical Effect: | Fetus / Decreased weight | |||
| Species | Effect Level | Dose | ||
| Rat | NOAEL | 60 mg/kg/day | ||
| References | ||||
| 1983 | NTP (National Toxicology Program). 1983. Teratologic evaluation of Phenol in CD rats. Report prepared by the Research Triangle Institute, Research Triangle Park, NC. NTIS PB83-247726. Govt Rep Announce Index. 83(25): 6247. | |||
| 1989 | U.S. EPA. 1989. Updated health effects assessment for Phenol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH, for the Office of Emergency and Remedial Response, Washington, DC | |||
| 1989 | U.S. EPA. 1989. RfD/RfC Work Group. | |||
| Subchronic [RfD] Comments: | Based on a developmental study with exposures during days 6-15 of gestation. The oral chronic RfD was adopted as the subchronic oral [RfD]. | |||
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