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Health Effects Assessment Summary (HEAST) for

Pentachlorophenol

CAS: 000087-86-5

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:IRIS
Oral [Unit Risk]:IRIS
EPA Group:IRIS





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)		 3E-2 mg/kg/day

Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Fetus / Fetotoxicity

Species Effect Level Dose Experiment Length
Rat NOEL 3 mg/kg/day 62 days

References
1978 Schwetz B.A., J.F. Quast, P.A. Keeler et al. 1978. Results of two-year toxicity and reproduction studies on Pentachlorophenol in rats. In: Pentachlorophenol: Chemistry, pharmacology and environmental toxicology, K.R. Rao, ed. Plenum Press, New York, p 301. Cited in U.S. EPA, 1985.
1986 U.S. EPA. 1986. Health and environmental effects profile for Pentachlorophenol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1984 U.S. EPA. 1984. Health effects assessment for Pentachlorophenol. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Emergency and Remedial Response, Washington, DC
1985 U.S. EPA. 1985. RfD/RfC Work Group.
Subchronic [RfD] Comments: Based on a teratology study with exposure 62 days prior to mating and throughout gestation and lactation.


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