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Health Effects Assessment Summary (HEAST) for

Pentachloronitrobenzene

CAS: 000082-68-8


Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Oral [Slope Factor]:on-Line
Oral [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line






Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]:
(see comment)
3E-3 mg/kg/day

Uncertainty Factor: 300

Route: Oral: diet

Target Organ / Critical Effect: Liver / Toxicity

Species Effect Level Dose Experiment Length
Dog NOEL 0.75 mg/kg/day 2 years

References
1968 Olin Corporation. 1968. MRID No. 000114201. Available from EPA. Write to FOI, EPA, Washington, DC 20460.
1986 U.S. EPA. 1986. Health and environmental effects profile for Pentachloronitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC
1987 U.S. EPA. 1987. RfD/RfC Work Group.

Subchronic [RfD] Comments: The chronic oral RfD was adopted as the subchronic oral [RfD].






Carcinogenicity

Oral [Slope Factor]:
(see comment)
2.6E-1 (mg/kg/day)-1


Oral [Unit Risk]: 7.4E-6 (µg/L)-1

Route: Oral

Target Organ / Cancer: Liver / Tumors

Species Experiment Length EPA Group
Mouse 72 weeks C

References
1969 Innes, J.R.M., B.M. Ulland, M.G. Valeria, et al. 1969. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J Natl Cancer Inst. 41: 1101-1114.
1986 U.S. EPA. 1986. Health and environmental effects profile for Pentachloronitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.

Oral Slope Comment: Under review, number subject to change.



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