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Health Effects Assessment Summary (HEAST) for
Pentachloronitrobenzene
CAS: 000082-68-8
Summary of HEAST Information on-Line
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Subchronic and Chronic Toxicity |
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Carcinogenicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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Subchronic [RfD]: (see comment) |
3E-3 mg/kg/day |
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Uncertainty Factor: |
300 |
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Route: |
Oral: diet |
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Target Organ / Critical Effect: |
Liver / Toxicity |
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Species |
Effect Level |
Dose |
Experiment Length |
Dog |
NOEL |
0.75 mg/kg/day |
2 years |
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References |
1968 | Olin Corporation. 1968. MRID No. 000114201. Available from EPA. Write to FOI, EPA, Washington, DC 20460. |
1986 | U.S. EPA. 1986. Health and environmental effects profile for Pentachloronitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
1987 | U.S. EPA. 1987. RfD/RfC Work Group. |
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Subchronic [RfD] Comments: |
The chronic oral RfD was adopted as the subchronic oral [RfD]. |
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Carcinogenicity |
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Oral [Slope Factor]: (see comment) |
2.6E-1 (mg/kg/day)-1 |
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Oral [Unit Risk]: |
7.4E-6 (µg/L)-1 |
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Route: |
Oral |
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Target Organ / Cancer: |
Liver / Tumors |
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Species |
Experiment Length |
EPA Group |
Mouse |
72 weeks |
C |
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References |
1969 | Innes, J.R.M., B.M. Ulland, M.G. Valeria, et al. 1969. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. J Natl Cancer Inst. 41: 1101-1114. |
1986 | U.S. EPA. 1986. Health and environmental effects profile for Pentachloronitrobenzene. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. |
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Oral Slope Comment: |
Under review, number subject to change. |
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