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Health Effects Assessment Summary (HEAST) for

Pentabromodiphenyl Ether

CAS: 032534-81-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfD]:IRIS
Subchronic [RfD]:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfD]: 2E-2 mg/kg/day
Uncertainty Factor: 100

Route: Oral: gavage

Target Organ / Critical Effect: Liver / Altered enzyme activities

Species Effect Level Dose Experiment Length
Rat NOAEL 1.8 mg/kg/day 90 days

References
1980 Carlson G.P. 1980. Induction of xenobiotic metabolism in rats by Brominated Diphenyl Ethers administered for 90 days. Toxicol Lett. 6: 207-212.
1983 U.S. EPA. 1983. Health and environmental effects profile for Brominated Diphenyl Ethers. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste, Washington, DC
1986 U.S. EPA. 1986. RfD/RfC Work Group.


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