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Health Effects Assessment Summary (HEAST) for
Octamethylpyrophosphoramide
CAS: 000152-16-9
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
2E-3 mg/kg/day |
| Uncertainty Factor: |
10 |
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| Subchronic [RfD]: |
2E-3 mg/kg/day |
| Uncertainty Factor: |
10 |
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| Route: |
Oral |
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| Target Organ / Critical Effect: |
Blood / Decreased cholinesterase activity |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Human |
NOAEL |
0.02 mg/kg/day |
≥ 30 days |
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| References |
| 1969 | Rider J.A., H.C. Moeller, E.J. Puletti and J.I. Swader. 1969. Toxicity of Parathion, Systox, Octamethylpyrophosphoramine and Methyl Parathion in man. Toxicol Appl Pharmacol. 14(3): 603-611. |
| 1989 | U.S. EPA. 1989. Health and environmental effects document for Octamethylpyrophosphoramide. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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