Health Effects Assessment Summary (HEAST) for
Nitrotoluene, p-
CAS: 000099-99-0
| Summary of HEAST Information on-Line | ||||||
| Subchronic and Chronic Toxicity | ||||||
|
| Chronic [RfD]: (see comment) |
1E-2 mg/kg/day | |||
| Uncertainty Factor: | 10000 | |||
| Subchronic [RfD]: (see comment) |
1E-1 mg/kg/day | |||
| Uncertainty Factor: | 1000 | |||
| Route: | Oral: gavage | |||
| Target Organ / Critical Effect: | Spleen / Lesions | |||
| Species | Effect Level | Dose | Experiment Length | |
| Rat | LOAEL | 200 mg/kg/day | 6 months | |
| References | ||||
| 1980 | Ciss M., N. Huyen, H. Dutertre, N. Phu-Lich and R. Truhaut. 1980. Toxicological study of Nitrotoluenes: Long-term toxicity. Dakar Medical. 25: 293-302. | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Nitrotoluenes (o-, m-, p-). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC | |||
| Subchronic [RfD] Comments: | Based on data obtained with o-nitrotoluene. | |||
| Chronic [RfD] Comments: | Based on data obtained with o-Nitrotoluene. | |||
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