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Health Effects Assessment Summary (HEAST) for
Nitrotoluene, o-
CAS: 000088-72-2
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
1E-2 mg/kg/day |
| Uncertainty Factor: |
10000 |
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| Subchronic [RfD]: |
1E-1 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Route: |
Oral: gavage |
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| Target Organ / Critical Effect: |
Spleen / Lesions |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Rat |
LOAEL |
200 mg/kg/day |
6 months |
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| References |
| 1980 | Ciss M., N. Huyen, H. Dutertre, N. Phu-Lich and R. Truhaut. 1980. Toxicological study of Nitrotoluenes: Long-term toxicity. Dakar Medical. 25: 293-302. |
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Nitrotoluenes (o-, m-, p-). Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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