Health Effects Assessment Summary (HEAST) for
Nitrosodiethylamine, N-
CAS: 000055-18-5
| Summary of HEAST Information on-Line | ||||||||||||
| Carcinogenicity | ||||||||||||
|
| Inhalation [Slope Factor]: (see comment) | 1.5E+2 (mg/kg/day)-1 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Cancer: | Liver / Tumors | |||
| Species | Experiment Length | EPA Group | ||
| Rat | 6 or 12 months | IRIS | ||
| References | ||||
| 1984 | Peto R., R. Gray, P. Brantom and P. Grasso. 1984. Nitrosamine carcinogenesis in 5120 rodents: Chronic administration of 16 different concentrations of NDEA, NDMA, NPYR and NPIP in the water of 4440 inbred rats, with parallel studies on NDEA alone of the effect of age of starting (3, 6 or 20 weeks) and of species (rats, mice or hamsters). Larc Sci Publ. 57: 627-665. | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Nitrosamines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| 1986 | U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Inhalation Slope Comment: | Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST. | |||
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