Health Effects Assessment Summary (HEAST) for
Nitroso-Di-n-Butylamine, n-
CAS: 000924-16-3
| Summary of HEAST Information on-Line | ||||||||||||
| Carcinogenicity | ||||||||||||
|
| Inhalation [Slope Factor]: (see comment) | 5.4E+0 (mg/kg/day)-1 | |||
| Route: | Oral: drinking water | |||
| Target Organ / Cancer: | Bladder / Tumors | |||
| Esophagus / Tumors | ||||
| Species | Experiment Length | EPA Group | ||
| Mouse | Lifetime | IRIS | ||
| References | ||||
| 1970 | Bertram J.S. and A.W. Craig. 1970. Induction of bladder tumors in mice with Dibutylnitrosamines. Br. J cancer. 24: 352-359. | |||
| 1986 | U.S. EPA. 1986. Health and environmental effects profile for Nitrosamines. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC. | |||
| 1986 | U.S. EPA. 1986. Carcinogen Risk Assessment Verification Endeavor (CRAVE) Work Group. | |||
| Inhalation Slope Comment: | Based on route to route extrapolation. See Appendix A-II, Dose Conversions on HEAST. | |||
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