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Health Effects Assessment Summary (HEAST) for

Nitropropane, 2-

CAS: 000079-46-9

Summary of HEAST Information on-Line

Subchronic and Chronic Toxicity
Chronic [RfC]:IRIS
Subchronic [RfC]:on-Line
Notes/Comments:on-Line
Carcinogenicity
Inhalation [Slope Factor]:on-Line
Inhalation [Unit Risk]:on-Line
EPA Group:on-Line
Notes/Comments:on-Line





Subchronic and Chronic Toxicity (Other than Carcinogenicity)

Subchronic [RfC]:
(see comment)		 2E-2 mg/cu m

Uncertainty Factor: 1000

Route: Inhalation: intermittent

Target Organ / Critical Effect: Liver / Lesions

Species Effect Level Dose Experiment Length
Rat LOAEL 78 mg/cu m 22 months

References
1985 Angus Chemical Co. 1985. Final report: Chronic inhalation exposure to rats to vapors of 2-Nitropropane at 100 ppm. Prepared by Coulston International Corp for Angus Chemical Co. OTS No. 204292. Doc. No. 8EHQ-0985-0170. Fiche No. 0200504.
1985 Angus Chemical Co. 1985. Chronic inhalation of 200 ppm of 2-Nitropropane in rats. Prepared by Coulston International Corp (May 1978) for Angus Chemical Co. OTS No. 204292. Doc. No. 8EHQ-0985-0170. Fiche No. 0200504
1980 Griffin T.B., F. Coulston and A.A. Stein. 1980. Chronic inhalation exposure of rats to vapors of 2-Nitropropane at 25 ppm. Ecotoxicol Environ Saf. 4(3): 267-281.
1981 Griffin T.B., A.A. Stein, F. Coulston. 1981. Histological study of tissues and organs from rats exposed to vapors of 2-Nitropropane at 25 ppm. Ecotoxocol Environ Saf. 5(2): 194-201.
1990 U.S. EPA. 1990. RfD/RfC Work Group.
Subchronic [RfC] Comments: The chronic inhalation RfC was adopted as the subchronic inhalation [RfC].





Carcinogenicity
Inhalation [Slope Factor]:
(see comment)		9.4E+0 (mg/kg/day)-1


Inhalation [Unit Risk]: 2.7E-3 (µg/m3)-1

Route: Inhalation: intermittent

Target Organ / Cancer: Liver / Tumors

Species Experiment Length EPA Group
Rat 22 months B2

References
1979 Lewis T.R., C.E. Ulrich and W.M. Busey. 1979. Subchronic inhalation toxicity of Nitromethane and 2-Nitropropane. J Environ Pathol Toxicol. 2(5): 233-249.
1985 U.S. EPA. 1985. Health and environmental effects profile for 2-Nitropropane. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC.
1988 U.S. EPA. 1988. Evaluation of the potential carcinogenicity of 2-Nitropropane. Prepared by the Carcinogen Assessment Group, Office of Health and Environmental Assessment, Washington, DC, for the Office of Emergency and Remedial Response, Washington, DC.
Inhalation Slope Comment: See Appendix A-II: Dose Conversions on HEAST.


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