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Health Effects Assessment Summary (HEAST) for
Nitrofurantoin
CAS: 000067-20-9
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Summary of HEAST Information on-Line
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| Subchronic and Chronic Toxicity |
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Subchronic and Chronic Toxicity
(Other than Carcinogenicity) |
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| Chronic [RfD]: |
7E-2 mg/kg/day |
| Uncertainty Factor: |
1000 |
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| Subchronic [RfD]: |
7E-1 mg/kg/day |
| Uncertainty Factor: |
100 |
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| Route: |
Oral: diet |
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| Target Organ / Critical Effect: |
Testis / Damage |
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| Species |
Effect Level |
Dose |
Experiment Length |
| Mouse |
NOAEL |
300 ppm |
13 weeks |
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| References |
| 1980 | SRI (Southern Research Institute). 1980. Subchronic toxicity report on Nitrofurantoin (C55196) in Fischer-344 rats and B6C3F1 mice. Tracor JIT Co, Inc, Rockville, MD, Contract Nos. N01-CP-43350 and 78-65-106002 U.S. EPA. |
| 1987 | U.S. EPA. 1987. Health and environmental effects document for Nitrofurans. Prepared by the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Cincinnati, OH for the Office of Solid Waste and Emergency Response, Washington, DC |
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